Data files

154 Data files visible to you, out of a total of 158

BACKGROUND:Animal experiments and studies in alcohol dependent patients indicate that ghrelin signaling in the brain is causally involved in the regulation of alcohol reward and intake. Increasing ghrelin levels enhances alcohol craving and intake, blocking ghrelin receptors abolishes these effects. If ghrelin is also involved in non-dependent alcohol consumption in humans, though, remains unknown. The aim was therefore to investigate the relationship between ghrelin serum levels and alcohol
...

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

The goal of this study was to investigate to what extent body mass index (BMI), body height, body
weight, breast-to-abdomen-ratio, testosterone, estradiol, dehydroepiandrosterone-sulfate (DHEA-S), folliclestimulating hormone, and luteinizing hormone are associated with the sound pressure level and the fundamental frequency of the speaking voice in a cross-sectional approach among adults in the general population.

Data for Publication: Jost L, et al; J Voice. 2017 Jul 21. pii: S0892-1997(17)30216-3.
...

Creators: René Hänsel, Christoph Engel

Contributor: René Hänsel

Data file type: Clinical Data

Improvement of efficacy of chemotherapy with CHOP-14 by additional therapy with the monoclonal antibody Rituximab and/or increase in cycle number from 6 to 8, measured by time to treatment failure

complete clinical data set for the clinical trial

Creators: René Hänsel, Marita Ziepert

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creators: René Hänsel, Marita Ziepert

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creators: René Hänsel, Marita Ziepert

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creators: René Hänsel, Marita Ziepert

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creators: René Hänsel, Marita Ziepert

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creators: René Hänsel, Marita Ziepert

Contributor: René Hänsel

Data file type: Clinical Data

Normative data concerning the speaking voice in the general population were gathered with the aim to establish standard values for clinical diagnostics. Associations between the speaking voice and sociodemographic factors were examined.

Creators: Christoph Engel, Martin Berg, Michael Fuchs, Kerstin Wirkner, Markus Löffler, Thomas Berger

Contributor: Christoph Beger

Data file type: Clinical Data

We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for Burkitt's lymphoma was generated, and chromosomal abnormalities were detected with interphase fluorescence in situ hybridization and array-based comparative genomic hybridization.

Creator: Michael Hummel

Contributor: Christoph Beger

Data file type: OMICs Data

We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 873 biopsy specimens including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt’s lymphoma (BL), mixed FL/DLBCL lymphomas, primary mediastinal large B-cell lymphoma (PMBL), multiple myeloma (MM), IRF4-rearranged large cell lymphoma, MYC-negative high-grade B-cell lymphomas with Chr. 11q aberration pattern (mnBLL-11q), and Mantle cell lymphoma (MCL).

Creator: Henry Löffler-Wirth

Contributor: Christoph Beger

Data file type: OMICs Data

Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed microarray-based genome- and transcriptome-wide molecular profiling of primary tumor samples from 137 patients with cerebral gliomas, 61 WHO grade II and 76 WHO grade III tumors.

Creator: Christoph Beger

Contributor: Christoph Beger

Data file type: OMICs Data

Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed microarray-based genome- and transcriptome-wide molecular profiling of primary tumor samples from 137 patients with cerebral gliomas, 61 WHO grade II and 76 WHO grade III tumors.

Creator: Christoph Beger

Contributor: Christoph Beger

Data file type: SOM Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

Gene expression of 270 patients with head and neck cancer
Within the Leipzig Head and Neck Group (LHNG) we designed an observational cohort study to include consecutive patients with primary and metachronous secondary HNSCC of oral cavity, larynx, oro-, and hypopharynx. All tumors were pathohistologically classified as head and neck squamous cell carcinoma (ICDO-M-8070/3, 8071/3, 8083/3). Excluded from the study were patients with prior history of cancer other than HNSCC within the last 5 years.
...

Creator: René Hänsel

Contributor: René Hänsel

Data file type: OMICs Data

No description specified

Creator: Christoph Engel

Contributors: Marita Ziepert, Christoph Beger

Data file type: Clinical Data

No description specified

Creator: Christoph Engel

Contributors: Marita Ziepert, Christoph Beger

Data file type: Clinical Data

No description specified

Creator: Christoph Engel

Contributors: Marita Ziepert, Christoph Beger

Data file type: Clinical Data

No description specified

Creator: Christoph Engel

Contributors: Marita Ziepert, Christoph Beger

Data file type: Clinical Data

No description specified

Creator: Christoph Engel

Contributors: Marita Ziepert, Christoph Beger

Data file type: Clinical Data

Progression free survival and overall survival of patients with brain tumors dependent on IDH1 mutation, methyltransferase (MGMT) methylation, age, WHO diagnosis and combinations of these factors.

Creators: Christoph Beger, Bettina Hentschel

Contributor: Christoph Beger

Data file type: Clinical Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

For a closer description, see the publication to which the file is attached.

Creators: Marcus Wagner, René Hänsel

Contributor: Marcus Wagner

Data file type: Image Data

ROIs of size 600 x 900 px (0.109 mm^2) size were chosen from 25 expert-specified tumor subregions within DLBCL biopsy specimens. Images were generated by Hamamatsu Nanozoomer 2.0 RS slide scanner. ROI no. 1 - 25 represent staining with CD14 antibody (imaged at 488 nm wavelength), ROI no. 26 -- 50 represent staining with CD163 antibody (imaged at 555 nm wavelength). Imaged regions in ROIs no. 1 and 26, 2 and 27, ... , coincide. Data were used for mutual comparison of automated macrophage recognition
...

Creators: René Hänsel, Marcus Wagner

Contributor: René Hänsel

Data file type: Image Data

No description specified

Creator: Silke Zachariae

Contributor: Silke Zachariae

Data file type: Not specified

trial data for the mental demandVariableMeaning Gender0=female1=maleMarital Status0 = married, living with partner1 = married and living separated, single, divorced, widowedEducation1 = low2 = medium3 = highEver_diabetes/ heart attack0 = no1 = yesDepression0 = no1 = yes

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Not specified

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creators: None

Contributor: Christoph Beger

Data file type: Not specified

No description specified

Creator: Christoph Beger

Contributor: Christoph Beger

Data file type: Not specified

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Trial data of MInT

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

MInT study result data as CIDISC ODM

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Not specified

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

MInT trial data as SPSS file

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

This file contains the metadata of the MInT study formatted as CDISC ODM.

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Based on the assumption that molecular mechanisms involved in cancerogenesis are characterized by groups of coordinately expressed genes, we developed and validated a novel method for analyzing transcriptional data called Correlated Gene Set Analysis (CGSA). Using 50 extracted gene sets we identified three different profiles of tumors in a cohort of 364 Diffuse large B-cell (DLBCL) and related mature aggressive B-cell lymphomas other than Burkitt lymphoma. The first profile had high level of
...

Creator: Maciej Rosolowski

Contributor: Christoph Beger

Data file type: OMICs Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Trial data as Microsoft Excel file

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Trial data as CDISC ODM file

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Trial data as SPSS file

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Trial data as Microsoft Excel file

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Trial data as CDISC ODM file

Creator: Marita Ziepert

Contributor: Christoph Beger

Data file type: Clinical Data

Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed Methylation profiling of primary tumor samples from 122 patients with cerebral gliomas with WHO grade II and grade III tumors.

Creator: Christoph Beger

Contributor: Christoph Beger

Data file type: OMICs Data

Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed Methylation profiling of primary tumor samples from 122 patients with cerebral gliomas with WHO grade II and grade III tumors.

Creator: Christoph Beger

Contributor: Christoph Beger

Data file type: OMICs Data

Data for visualisation of associations and causal relationsships of SNPs, gene expression, and metabolites based on 1,856 individuals of the LIFE Heart study

Creator: Christoph Beger

Contributor: Christoph Beger

Data file type: OMICs Data

Cognitive assessments comprised tests from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD): verbal fluency (VF), word list learning and recall (WLL, WLR), and the Trail Making Tests (TMT) A and B. The "Sniffin' Sticks Screening 12" test was used to measure olfactory performance. Linear regression analyses were performed to determine associations between the number of correctly identified odors (0 to 12) and the five cognitive test scores, adjusted for sex, age, education,
...

Creator: Christoph Engel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

A total of 2695 individuals (age 40-79 years, 48% men) without prior diagnosis of diabetes and complete measurement of HbA1c, FPG, 2 h-PG and urine albumin-creatinine ratio (UACR) were taken from a large population-based epidemiological study in the City of Leipzig, Germany.

Diabetes screening strategies using glycated haemoglobin (HbA1c) as first-instance diagnostic parameter may cause failure to detect individuals with abnormal glucose regulation and possible signs of microvascular complications
...

Creator: Christoph Engel

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Not specified

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Not specified

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Not specified

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)
Sample Size: 164

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Not specified

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

BACKGROUND: Reference intervals for leukocyte subsets from peripheral blood are helpful for the understanding of disease states and therapy effects. METHODS: We performed in-depth immunophenotyping for 608 healthy German adults from the Leipzig region from 40 to 79 years by 10-color flow cytometry (FCM) to gain reference information for various leukocyte subsets including subsets of granulocytes, monocytes and lymphocytes. RESULTS: First, we derived gender- and age-specific reference intervals
...

Creator: Silke Zachariae

Contributor: Silke Zachariae

Data file type: Not specified

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: Maciej Rosolowski

Contributors: Maciej Rosolowski, Christoph Beger

Data file type: SOM Data

We present an extensive and detailed study on the gene expression landscape of peripheral blood of healthy individuals based on transcriptome data of 3,388 individuals screened in the population study LIFE between 2011 and 2014. For analysis we applied a neural network technique using self-organizing maps (SOM). Our home-made R-program ‘oposSOM’ enables to reduce the dimension of expression data from tens of thousands of genes to a few thousand ‘meta-genes’ and generates portraits of transcriptional
...

Creator: Henry Löffler-Wirth

Contributors: Henry Löffler-Wirth, Christoph Beger

Data file type: SOM Data

We performed gene-expression analysis of 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A SOM was trained using molecular classification of specimen according to molecular Burkitt's Lymphoma score provided by Hummel et al.

Creator: Henry Löffler-Wirth

Contributors: Henry Löffler-Wirth, Christoph Beger

Data file type: SOM Data

We present a transcriptome map of mature B-cell lymphomas that was obtained by analyzing expression data of 873 biopsy specimens including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt’s lymphoma (BL), mixed FL/DLBCL lymphomas, primary mediastinal large B-cell lymphoma (PMBL), multiple myeloma (MM), IRF4-rearranged large cell lymphoma, MYC-negative high-grade B-cell lymphomas with Chr. 11q aberration pattern (mnBLL-11q), and Mantle cell lymphoma (MCL) to describe their
...

Creator: Henry Löffler-Wirth

Contributors: Henry Löffler-Wirth, Christoph Beger

Data file type: SOM Data

Colorectal cancer (CRC) arising in Lynch syndrome (LS) comprises tumours with constitutional mutations in DNA mismatch repair genes. There is still a lack of whole-genome and transcriptome studies of LS-CRC to address questions about similarities and differences in mutation and gene expression characteristics between LS-CRC and sporadic CRC, about the molecular heterogeneity of LS-CRC, and about specific mechanisms of LS-CRC genesis linked to dysfunctional mismatch repair in LS colonic mucosa and
...

Creator: Hans Binder

Contributor: Christoph Beger

Data file type: SOM Data

For this study, we screened prospectively recruited patients with a histopathological reference diagnosis of cerebral tumors of WHO grade II and III, known KPS at diagnosis, information on extent of resection by early postoperative neuroimaging, available frozen tissue specimens from the initial operation, and documented clinical outcome.

Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological
...

Creators: René Hänsel, Henry Löffler-Wirth

Contributor: René Hänsel

Data file type: SOM Data

Single-cell transcriptomics has been used for analysis of heterogeneous populations of cells during developmental processes and for analysis of tumor cell heterogeneity. More recently, analysis of pseudotime (PT) dynamics of heterogeneous cell populations has been established as a powerful concept to study developmental processes. Here we perform PT analysis of 3 melanoma short-term cultures with different genetic backgrounds to study specific and concordant properties of PT dynamics of selected
...

Creators: René Hänsel, Henry Löffler-Wirth

Contributor: René Hänsel

Data file type: SOM Data

Recent technological advances in single-cell genomics make it possible to analyze cellular heterogeneity of tumor samples. Here, we applied single-cell RNA-seq to measure the transcriptomes of 307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS wild type, BRAF mutant/NRAS wild type and BRAF wild type/NRAS mutant melanoma metastasis, respectively. Analysis based on self-organizing maps identified sub-populations defined by multiple gene expression modules
...

Creator: Henry Löffler-Wirth

Contributor: René Hänsel

Data file type: SOM Data

307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS wild type, BRAF mutant/NRAS wild type and BRAF wild type/NRAS mutant melanoma metastasis, respectively

Creators: Christoph Beger, Manfred Kunz

Contributor: Christoph Beger

Data file type: OMICs Data

No description specified

Creator: Christoph Beger

Contributor: Christoph Beger

Data file type: Not specified

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

No description specified

Creator: René Hänsel

Contributor: René Hänsel

Data file type: Clinical Data

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