Projects

Rare diseases (RD) occur with a prevalence of less than 1:2,000 persons (EU definition). More than 8,000 RD are known, often genetically determined. Due to their rare occurrence, the RD are often not diagnosed at all, incorrectly or with a long delay diagnosed. Medical experts are mainly involved in selected Centers for Rare Diseases available.The goal of the LEUKO-Expert project is to establish an expert system for the diagnostic support of RD Leukodystrophy and to evaluate it within the scope ...

The cultivated grape (Vitis vinifera) has become the world’s leading fruit crop. Grape is unique not only because it is a major global perennial crop but also for its historical and cultural connections with the development of humans. One of the main challenges for viticulture is to sustainably maintain the production of high-quality grape varieties in the face of climate change. Current models predict an increasing disease pressure for grapes, mainly because of warmer and partly drier conditions. ...

Background Single-cell RNA sequencing (scRNAseq) has been widely applied to dissect cellular heterogeneity in normal and diseased skin. Sebaceous glands, essential skin components with established functions in maintaining skin integrity and emerging roles in systemic energy metabolism, have been largely neglected in scRNAseq studies. Methods Departing from mouse and human skin scRNAseq datasets, we identified gene sets expressed especially in sebaceous glands with the open-source R-package oposSOM. ...

The study employed high quality non-mydriatic (i.e. pupil dilation is not required) fundus photography (FP) (Oculus Nidek AFC-230, 45 FOV) and a infra-red reflectance (IR) en face image obtained by scanning laser ophthalmoscope (SLO) (Heidelberg Spectralis, 30 FOV) to produce representative images of the retina and optic nerve. In order to prove the scale invariance property of tortuosity metrics, ophthalmological photographs from 18 subjects, both eyes, were randomly extracted from the ...

Generating and evaluating synthetic data in the medical domain. The synthetic data could be tabular or image.