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Molecular mechanisms in malignant lymphoma (Institute for Medical Informatics, Statistics and Epidemiology) ; LIFE Heart (Institute for Medical Informatics, Statistics and Epidemiology) ; LIFE Head and Neck Cancer Group (Institute for Medical Informatics, Statistics and Epidemiology) ; MMML-MYC-SYS (Institute for Medical Informatics, Statistics and Epidemiology) ; German Glioma Network (Institute for Medical Informatics, Statistics and Epidemiology)
Goal of the Leipzig Research Center for Civilization Diseases (LIFE) is the investigation of civilization diseases like depression, diabetes, allergies or cardiovascular diseases. For this purpose we collect as much data as possible regarding health and living conditions of the population in Leipzig and provide these data for scientists of the University of Leipzig and other research institutions.
The aim of the Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) is to facilitate improvements in the treatment and care of head and neck cancer patients through insights from molecular studies.
The Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) investigates the molecular mechanisms and the diagnostic and prognostic factors of head and neck cancer. For this purpose, we collected phenotypic information from about 300
During 2004 and 2012 the german cancer aid supported the german glioma network (GGN). The GGN is a consortium where university hospitals with clinical focus in neuro-oncology, reference centers for neuroradiology, neuropathology, molecular diagnostics and biometry cooperate. Thanks to the long-term support it was possible to build a network of competence centers for the treatment of brain tumors in Germany wich is characterized by a interdisciplinary collaboration of all specialist disciplines
B-cell lymphoma is the most frequent lymphoid neoplasia accounting for one third of all lymphomas. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) is the current treatment standard, leading to high cure rates especially in younger patients. Although the 3-year event-free survival is about 60% even for elderly patients between 60-80 years old, the remainder of patients eventually relapse and the majority die of their disease. The German Non-Hodgkin's Lymphoma Study
The LIFE-Heart study recruited 7,000 patients with suspected coronary heart disease, manifest heart disease or myocardial infarction. All patients received coronary angiography so that the vascular status in the heart is precisely known. In principle, this examination is not feasible in population-related studies. In addition, the patients were thoroughly examined with regard to the general vascular status and the health of the cardiovascular system. Extensive environmental factors were recorded.
Authors: Henry Löffler-Wirth, Markus Kreuz, Lydia Hopp, A. Arakelyan, A. Haake, S. B. Cogliatti, A. C. Feller, M. L. Hansmann, D. Lenze, P. Moller, H. K. Muller-Hermelink, E. Fortenbacher, E. Willscher, G. Ott, A. Rosenwald, C. Pott, C. Schwaenen, H. Trautmann, S. Wessendorf, H. Stein, M. Szczepanowski, L. Trumper, Michael Hummel, W. Klapper, R. Siebert, Markus Löffler, Hans Binder
Date Published: 30th Apr 2019
Journal: Genome Med
PubMed ID: 31039827
Citation: Genome Med. 2019 Apr 30;11(1):27. doi: 10.1186/s13073-019-0637-7.
Authors: T. Zenz, Markus Kreuz, M. Fuge, W. Klapper, H. Horn, A. M. Staiger, D. Winter, H. Helfrich, J. Huellein, M. L. Hansmann, H. Stein, A. Feller, P. Moller, N. Schmitz, L. Trumper, Markus Löffler, R. Siebert, A. Rosenwald, G. Ott, M. Pfreundschuh, S. Stilgenbauer
Date Published: 1st Oct 2017
Journal: Int J Cancer
PubMed ID: 28614910
Citation: Int J Cancer. 2017 Oct 1;141(7):1381-1388. doi: 10.1002/ijc.30838. Epub 2017 Jun 26.
Date Published: 30th Jun 2016
Journal: Genes Chromosomes Cancer
Human Diseases: diffuse large B-cell lymphoma
PubMed ID: 27356265
Citation: Genes Chromosomes Cancer. 2016 Dec;55(12):932-943. doi: 10.1002/gcc.22391. Epub 2016 Jul 12.
Date Published: 2nd Feb 2016
Journal: Neurobiol Aging
Human Diseases: Not specified
PubMed ID: 26827656
Citation: Neurobiol Aging. 2016 Feb;38:181-187. doi: 10.1016/j.neurobiolaging.2015.11.003. Epub 2015 Nov 11.
Authors: G. Wichmann, Maciej Rosolowski, K. Krohn, Markus Kreuz, A. Boehm, A. Reiche, U. Scharrer, D. Halama, J. Bertolini, U. Bauer, D. Holzinger, M. Pawlita, J. Hess, Christoph Engel, D. Hasenclever, Markus Scholz, P. Ahnert, Toralf Kirsten, A. Hemprich, C. Wittekind, O. Herbarth, F. Horn, A. Dietz, Markus Löffler
Date Published: 15th Dec 2015
Journal: Int J Cancer
Human Diseases: head and neck cancer
PubMed ID: 26095926
Citation: Int J Cancer. 2015 Dec 15;137(12):2846-57. doi: 10.1002/ijc.29649. Epub 2015 Jul 6.