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Web page: http://www.imise.uni-leipzig.de/en/
Country: Germany
City: Leipzig
Address:
Institut für Medizinische Informatik, Statistik und Epidemiologie
Universität Leipzig
Härtelstraße 16-18
04107 Leipzig
GERMANY
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The aim of this project is to validate and improve an in vitro test system developed in a previous project for the prediction of hepatotoxicity induced by chemical substances and drugs. For this purpose, the test system will be supplemented with immunological cells in order to be able to detect idiosyncratic reactions. In the subproject of the working group of Prof. Daniel Seehofer and Dr. Georg Damm, primary liver cells will be provided and the in vitro model will be improved by Kupffer cells.
Programme: This Project is not associated with a Programme
Public web page: Not specified
Start date: 1st Feb 2017
End date: 31st Dec 2020
Organisms: Homo sapiens
Human Diseases: liver disease
This population-based study examined 10,000 participants randomly selected from the Leipzig population (2011 to 2014). A follow-up is to be carried out from 2017 - 2020. The study mainly included people aged between 40 and 79. All participants underwent a 6-hour study program and people over 60 years of age were invited two more times to in-depth study of cognition and depression and the brain (MRI, EEG). Extensive measurements of genome, metabolome and transcriptome are available. The LIFE-ADULT
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Programme: Epidemiology
Public web page: http://life.uni-leipzig.de/en/adults/life_adult.html
Start date: 1st Jan 2009
Organisms: Homo sapiens
Human Diseases: mood disorder, dementia, coronary artery disease, obesity
Goal of the Leipzig Research Center for Civilization Diseases (LIFE) is the investigation of civilization diseases like depression, diabetes, allergies or cardiovascular diseases. For this purpose we collect as much data as possible regarding health and living conditions of the population in Leipzig and provide these data for scientists of the University of Leipzig and other research institutions.
The Leipzig Health Atlas (LHA) is an alliance of medical ontologists, medical systems biologists and clinical trials groups to design and implement a multi-functional and quality-assured atlas. It provides models, data and metadata on specific use cases from medical research fields in which our team has scientific and clinical expertise.
Programme: This Project is not associated with a Programme
Public web page: https://www.health-atlas.de
Start date: 1st Apr 2016
End date: 28th Feb 2021
Organisms: Homo sapiens
Projects: LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer
Institutions: Institute for Medical Informatics, Statistics and Epidemiology

Expertise: hereditary cancer, biometry, epidemiology
Projects: GGN - German Glioma Network
Institutions: Institute for Medical Informatics, Statistics and Epidemiology
Bettina Hentschel
Contact Institution
IMISE
Härtelstr. 16-18
04107 Leipzig