René Hänsel
LHA ID: 7W0F9NVPXN-6
Location:
Germany
ORCID:
https://orcid.org/0000-0001-8344-0658
Joined: 12th Apr 2019
Expertise: Data Management, Data analysis, Python, Html
Tools: Not specified
Project roles
Project administrator
- MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine
- COVID-19 Leipzig
- LivSys Transfer - Transfer of the LivSys in vitro system for hepatotoxicity into application
- Project Test Demonstrator
- LIFE Heart
- LIFE HNC - Head and Neck Cancer Group
- ProstataCA
- HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome
- HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia
- HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles
- MMML - Molecular mechanisms in malignant lymphoma
- GLA - German Lymphoma Alliance
- MMML-MYC-SYS
- GGN - German Glioma Network
- CapSys - Systems Medicine of Community Acquired Pneumonia
- CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome
- e:Med
Asset gatekeeper
- MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine
- Project Test Demonstrator
Asset housekeeper
Their tagsLHA - Leipzig Health Atlas (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; COVID-19 Leipzig (Institute for Medical Informatics, Statistics and Epidemiology (IMISE))
HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; e:Med (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; CapSys - Systems Medicine of Community Acquired Pneumonia (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; LIFE Adult (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; LIFE HNC - Head and Neck Cancer Group (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; LIFE - Leipzig Research Center for Civilization Diseases (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; LIFE Child (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; GLA - German Lymphoma Alliance (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; MMML-MYC-SYS (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; MMML - Molecular mechanisms in malignant lymphoma (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; NLP4CR - Natural Language Processing for Clinical Research (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; LIFE Heart (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; ProstataCA (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; SepNet - German Competence Network Sepsis (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; Genetical Statistics and Systems Biology (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; GGN - German Glioma Network (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; SMITH - Smart Medical Information Technology for Healthcare (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; Management of health information systems (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; LivSys Transfer - Transfer of the LivSys in vitro system for hepatotoxicity into application (Institute for Medical Informatics, Statistics and Epidemiology (IMISE)) ; Project Test Demonstrator (Institute for Medical Informatics, Statistics and Epidemiology (IMISE))
Related items
The group is interested in omic-level studies including the genome, methylome, transcriptome, and metabolome of the general population as well as of various diseases including cardiovascular diseases, pneumonia, sepsis, obesity, and brain cancers. Additionally, we aim at transfering results of biomathematical model simulations into clinical practice e.g. by haematopoietic growth-factor opimization during cytotoxic chemotherapy and optimization of EPO applications in chronic kidney disease.
The ...
Programme: This Project is not associated with a Programme
Public web page: http://www.imise.uni-leipzig.de/en/Groups/GenStat/
Start date: 1st Jan 2013
e:Med has the objective of establishing systems medicine in Germany. e:Med promotes system-oriented research into diseases in order to facilitate improved prevention, more comprehensive diagnostics and individually adjusted therapy schemes in individualized medicine. The program brings together scientists with molecular-genetic, clinical, mathematical and information technology expertise, with the objective of ensuring that research results quickly benefit patients.
Programme: Default Programme
Public web page: https://www.sys-med.de/en/
Programme: This Project is not associated with a Programme
Public web page: Not specified
The central objective of HaematoOpt project is to demonstrate that recently developed dynamic mathematical models of normal and leukemic hematopoiesis can be used to practically impact clinical decision- making
Programme: This Project is not associated with a Programme
Public web page: https://haematoopt.de/
In the interdisciplinary consortium HaematoSys partners from leading clinical haematooncological study groups, pathologists, geneticists, cell biologists as well as mathematicians, statisticians and bioinformaticians have joined forces.
Programme: NHL
Public web page: https://www.haematosys.de
CAPSyS is an interdisciplinary research network that investigates the causes and course of severe pneumonia. The network works in five subprojects at seven locations throughout Germany. CAPSyS is funded by the Federal Ministry of Education and Research (BMBF) with 3.8 million euros.
Programme: This Project is not associated with a Programme
Public web page: https://www.capsys.imise.uni-leipzig.de
Start date: 1st Jan 2014
End date: 1st Jan 2019
Programme: This Project is not associated with a Programme
Public web page: Not specified
Start date: 1st Jan 2017
Programme: MII - Medical Informatics Initiative
Public web page: https://www.smith.care/
Start date: 1st Jan 2018
This project serves as a container for all COVID-19 related assets, developed at the University of Leipzig and its partners.
The Leipzig Health Atlas (LHA) is an alliance of medical ontologists, medical systems biologists and clinical trials groups to design and implement a multi-functional and quality-assured atlas. It provides models, data and metadata on specific use cases from medical research fields in which our team has scientific and clinical expertise.
Programme: This Project is not associated with a Programme
Public web page: https://www.health-atlas.de
Start date: 1st Apr 2016
End date: 28th Feb 2021
Resutls of different OMICS-level using LIFE Adult and LIFE Heart data are presented (Publications, Supplemental Data, & Summary Statistics).
Submitter: René Hänsel
Studies: GWAMA PCSK9, GWAMA Phytosterole, GWAMA Steroid hormones, GWAS Body Scanner Measures, GWAS Carotid Plaque Burden, GWAS Pulse Wave Velocity, GWAS Steroid Hormones, scRNA-Seq across species for pulmonologists
Resources: Summary Statistic for PWV GWAS, Summary Statistics, Summary Statistics, Summary Statistics, Summary Statistics, Summary Statistics - Phytosterols, Supplement Data, scRNA-Seq expression data as RDS Seurat file
Submitter: René Hänsel
Studies: Covid-19 Data Source Research
Resources: Covid-19 Data Sources Germany, Covid-19 Data Sources worldwide
Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status
ROF filter based segmentation methods will be employed for automated recognition of macrophages, B-cells and cell nuclei within the tissue samples.
Mega-CHOEP phase III is a randomised study comparing conventional chemoimmunotherapy with R-CHOEP-14 with high-dose chemotherapy plus Rituximab with autologous stem cell transplantation in high-risk patients aged 61 to 80 years with Aggressive Non-Hodgkin’s Lymphoma.
RICOVER-60 is a randomised study comparing 6 and 8 cycles of chemotherapy with CHOP (Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) at 14-day intervals (CHOP-14), both with or without the monoclonal anti-CD20 antibody Rituximab in patients aged 61 to 80 years with Aggressive Non-Hodgkin’s Lymphoma.
Submitter: René Hänsel
Studies: RICOVER-60
Resources: RICOVER-60 trial data, RICOVER-60 trial metadata
Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)
Submitter: René Hänsel
Investigation: FLYER
Resources: FLYER trial data, FLYER trial metadata
Study type: Not specified
Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)
Submitter: René Hänsel
Investigation: ACT-2
Resources: ACT-2 trial data, ACT-2 trial metadata
Study type: Not specified
Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)
Submitter: René Hänsel
Investigation: SEXIE-R-CHOP-14
Resources: SEXIE-R-CHOP-14 metadata, SEXIE-R-CHOP-14 trial data
Study type: Not specified
Submitter: René Hänsel
Investigation: Covid-19
Resources: Covid-19 Data Sources Germany, Covid-19 Data Sources worldwide
Study type: Not specified
Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)
Submitter: René Hänsel
Investigation: OMICS Investigations
Resources: Summary Statistics, Supplement Data
Study type: Genetic study
Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status
Submitter: René Hänsel
Investigation: head and neck squamous cell carcinomas
Resources: HNSCC Clinical Dataset, HNSCC OMICS Data
Study type: Clinical study (Phase 1)
Submitter: René Hänsel
Investigation: HighCHOEP phase 2
Resources: No Resources
Study type: Not specified
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: ACT-2
Study: ACT-2
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: FLYER
Study: Flyer
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: FLYER
Study: Flyer
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: ACT-2
Study: ACT-2
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: head and neck squamous cell carcinomas
Study: HNSCC
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: head and neck squamous cell carcinomas
Study: HNSCC
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: Covid-19
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: Covid-19
The primary goal of this study was to identify genetic loci associated with steroid hormone levels (cortisol, DHEA-S, testosterone, estradiol, progesterone, 17-hydroxyprogesterone, androstenedione, and aldosterone). In a secondary analysis, we searched for causal effects of steroid hormones on coronary artery disease.
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: OMICS Investigations
Study: GWAS Steroid Hormones
Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival) Sample Size: 189
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: SMARTE-R-CHOP-14
Study: SMARTE-R-CHOP-14
Abstract (Expand)
Authors: A. Uciteli, C. Beger, J. Wagner, A. Kiel, F. A. Meineke, S. Staubert, M. Lobe, R. Hansel, J. Schuster, T. Kirsten, H. Herre
Date Published: 24th May 2021
Publication Type: Journal article
Abstract (Expand)
Authors: Andrea Zimmermann, René Hänsel, Kilian Gemünden, Victoria Kegel-Hübner, Jonas Babel, Hendrik Bläker, Madlen Matz-Soja, Daniel Seehofer, Georg Damm
Date Published: 1st Apr 2021
Publication Type: Journal article
Human Diseases: liver disease, liver cancer
Abstract (Expand)
Authors: Nasim Mavaddat, Antonis C. Antoniou, Thea M. Mooij, Maartje J. Hooning, Bernadette A. Heemskerk-Gerritsen, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, Alain Lortholary, Daniel Barrowdale, Debra Frost, D. Gareth Evans, Louise Izatt, Julian Adlard, Ros Eeles, Carole Brewer, Marc Tischkowitz, Alex Henderson, Jackie Cook, Diana Eccles, Klaartje van Engelen, Marian J. E. Mourits, Margreet G. E. M. Ausems, Linetta B. Koppert, John L. Hopper, Esther M. John, Wendy K. Chung, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Javier Benitez, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Christian F. Singer, Yen Tan, Edith Olah, Marie Navratilova, Lenka Foretova, Anne-Marie Gerdes, Marie-José Roos-Blom, Flora E. van Leeuwen, Brita Arver, Håkan Olsson, Rita K. Schmutzler, Christoph Engel, Karin Kast, Kelly-Anne Phillips, Mary Beth Terry, Roger L. Milne, David E. Goldgar, Matti A. Rookus, Nadine Andrieu, Douglas F. Easton
Date Published: 1st Dec 2020
Publication Type: Journal article
Human Diseases: hereditary breast ovarian cancer syndrome
Abstract
Authors: Nasim Mavaddat, Antonis C. Antoniou, Thea M. Mooij, Maartje J. Hooning, Bernadette A. Heemskerk-Gerritsen, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, Alain Lortholary, Daniel Barrowdale, Debra Frost, D. Gareth Evans, Louise Izatt, Julian Adlard, Ros Eeles, Carole Brewer, Marc Tischkowitz, Alex Henderson, Jackie Cook, Diana Eccles, Klaartje van Engelen, Marian J. E. Mourits, Margreet G. E. M. Ausems, Linetta B. Koppert, John L. Hopper, Esther M. John, Wendy K. Chung, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Javier Benitez, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Christian F. Singer, Yen Tan, Edith Olah, Marie Navratilova, Lenka Foretova, Anne-Marie Gerdes, Marie-José Roos-Blom, Flora E. van Leeuwen, Brita Arver, Håkan Olsson, Rita K. Schmutzler, Christoph Engel, Karin Kast, Kelly-Anne Phillips, Mary Beth Terry, Roger L. Milne, David E. Goldgar, Matti A. Rookus, Nadine Andrieu, Douglas F. Easton
Date Published: 1st Dec 2020
Publication Type: Journal article
Human Diseases: hereditary breast ovarian cancer syndrome
Abstract (Expand)
Authors: Neda Baniasadi, Franziska G. Rauscher, Dian Li, Mengyu Wang, Eun Young Choi, Hui Wang, Thomas Peschel, Kerstin Wirkner, Toralf Kirsten, Joachim Thiery, Christoph Engel, Markus Loeffler, Tobias Elze
Date Published: 3rd Aug 2020
Publication Type: Journal article
Abstract (Expand)
Authors: Valentina Silvestri, Goska Leslie, Daniel R. Barnes, Bjarni A. Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L. Andrulis, Rosa B. Barkardottir, Alicia Barroso, Daniel Barrowdale, Javier Benitez, Bernardo Bonanni, Ake Borg, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Carlo Capalbo, Ian Campbell, Wendy K. Chung, Kathleen B. M. Claes, Sarah V. Colonna, Laura Cortesi, Fergus J. Couch, Miguel de La Hoya, Orland Diez, Yuan Chun Ding, Susan Domchek, Douglas F. Easton, Bent Ejlertsen, Christoph Engel, D. Gareth Evans, Lidia Feliubadalò, Lenka Foretova, Florentia Fostira, Lajos Géczi, Anne-Marie Gerdes, Gord Glendon, Andrew K. Godwin, David E. Goldgar, Eric Hahnen, Frans B. L. Hogervorst, John L. Hopper, Peter J. Hulick, Claudine Isaacs, Angel Izquierdo, Paul A. James, Ramunas Janavicius, Uffe Birk Jensen, Esther M. John, Vijai Joseph, Irene Konstantopoulou, Allison W. Kurian, Ava Kwong, Elisabetta Landucci, Fabienne Lesueur, Jennifer T. Loud, Eva Machackova, Phuong L. Mai, Keivan Majidzadeh-A, Siranoush Manoukian, Marco Montagna, Lidia Moserle, Anna Marie Mulligan, Katherine L. Nathanson, Heli Nevanlinna, Joanne Ngeow Yuen Ye, Liene Nikitina-Zake, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Ana Osorio, Laura Papi, Sue K. Park, Inge Sokilde Pedersen, Pedro Perez-Segura, Annabeth H. Petersen, Pedro Pinto, Berardino Porfirio, Miquel Angel Pujana, Paolo Radice, Johanna Rantala, Muhammad U. Rashid, Barak Rosenzweig, Maria Rossing, Marta Santamariña, Rita K. Schmutzler, Leigha Senter, Jacques Simard, Christian F. Singer, Angela R. Solano, Melissa C. Southey, Linda Steele, Zoe Steinsnyder, Dominique Stoppa-Lyonnet, Yen Yen Tan, Manuel R. Teixeira, Soo H. Teo, Mary Beth Terry, Mads Thomassen, Amanda E. Toland, Sara Torres-Esquius, Nadine Tung, Christi J. van Asperen, Ana Vega, Alessandra Viel, Jeroen Vierstraete, Barbara Wappenschmidt, Jeffrey N. Weitzel, Greet Wieme, Sook-Yee Yoon, Kristin K. Zorn, Lesley McGuffog, Michael T. Parsons, Ute Hamann, Mark H. Greene, Judy A. Kirk, Susan L. Neuhausen, Timothy R. Rebbeck, Marc Tischkowitz, Georgia Chenevix-Trench, Antonis C. Antoniou, Eitan Friedman, Laura Ottini
Date Published: 2nd Jul 2020
Publication Type: Journal article
Human Diseases: hereditary breast ovarian cancer syndrome
Abstract (Expand)
Authors: Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Zomoroda Abu-Full, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Antonis C. Antoniou, Adalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Paul L. Auer, Jacopo Azzollini, Judith Balmaña, Rosa B. Barkardottir, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Katarzyna Białkowska, Ana Blanco, Carl Blomqvist, Bram Boeckx, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Ake Borg, Hiltrud Brauch, Hermann Brenner, Ignacio Briceno, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Qiuyin Cai, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Sander Canisius, Daniele Campa, Brian D. Carter, Jonathan Carter, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Hans Christiansen, Wendy K. Chung, Kathleen B. M. Claes, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Cezary Cybulski, Kamila Czene, Mary B. Daly, Miguel de La Hoya, Kim de Leeneer, Joe Dennis, Peter Devilee, Orland Diez, Susan M. Domchek, Thilo Dörk, Isabel Dos-Santos-Silva, Alison M. Dunning, Miriam Dwek, Diana M. Eccles, Bent Ejlertsen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Marike Gabrielson, Patricia A. Ganz, Susan M. Gapstur, Judy Garber, Montserrat García-Closas, José A. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González-Neira, Mark H. Greene, Jacek Gronwald, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Christopher Hake, Wei He, Jane Heyworth, Frans B. L. Hogervorst, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Guanmengqian Huang, Peter J. Hulick, Keith Humphreys, Evgeny N. Imyanitov, Claudine Isaacs, Milena Jakimovska, Anna Jakubowska, Paul James, Ramunas Janavicius, Rachel C. Jankowitz, Esther M. John, Nichola Johnson, Vijai Joseph, Audrey Jung, Beth Y. Karlan, Elza Khusnutdinova, Johanna I. Kiiski, Irene Konstantopoulou, Vessela N. Kristensen, Yael Laitman, Diether Lambrechts, Conxi Lazaro, Dominique Leroux, Goska Leslie, Jenny Lester, Fabienne Lesueur, Noralane Lindor, Sara Lindström, Wing-Yee Lo, Jennifer T. Loud, Jan Lubiński, Enes Makalic, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, John W. M. Martens, Maria E. Martinez, Laura Matricardi, Tabea Maurer, Dimitrios Mavroudis, Lesley McGuffog, Alfons Meindl, Usha Menon, Kyriaki Michailidou, Pooja M. Kapoor, Austin Miller, Marco Montagna, Fernando Moreno, Lidia Moserle, Anna M. Mulligan, Taru A. Muranen, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Ines Nevelsteen, Finn C. Nielsen, Liene Nikitina-Zake, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Håkan Olsson, Ana Osorio, Janos Papp, Tjoung-Won Park-Simon, Michael T. Parsons, Inge S. Pedersen, Ana Peixoto, Paolo Peterlongo, Julian Peto, Paul D. P. Pharoah, Kelly-Anne Phillips, Dijana Plaseska-Karanfilska, Bruce Poppe, Nisha Pradhan, Karolina Prajzendanc, Nadege Presneau, Kevin Punie, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Harvey A. Risch, Mark Robson, Atocha Romero, Emmanouil Saloustros, Dale P. Sandler, Catarina Santos, Elinor J. Sawyer, Marjanka K. Schmidt, Daniel F. Schmidt, Rita K. Schmutzler, Minouk J. Schoemaker, Rodney J. Scott, Priyanka Sharma, Xiao-Ou Shu, Jacques Simard, Christian F. Singer, Anne-Bine Skytte, Penny Soucy, Melissa C. Southey, John J. Spinelli, Amanda B. Spurdle, Jennifer Stone, Anthony J. Swerdlow, William J. Tapper, Jack A. Taylor, Manuel R. Teixeira, Mary Beth Terry, Alex Teulé, Mads Thomassen, Kathrin Thöne, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Thérèse Truong, Nadine Tung, Celine M. Vachon, Christi J. van Asperen, Ans M. W. van den Ouweland, Elizabeth J. van Rensburg, Ana Vega, Alessandra Viel, Paula Vieiro-Balo, Qin Wang, Barbara Wappenschmidt, Clarice R. Weinberg, Jeffrey N. Weitzel, Camilla Wendt, Robert Winqvist, Xiaohong R. Yang, Drakoulis Yannoukakos, Argyrios Ziogas, Roger L. Milne, Douglas F. Easton, Georgia Chenevix-Trench, Wei Zheng, Peter Kraft, Xia Jiang
Abstract (Expand)
Authors: G. G. Wulf, B. Altmann, M. Ziepert, F. D'Amore, G. Held, R. Greil, O. Tournilhac, T. Relander, A. Viardot, M. Wilhelm, C. Wilhelm, A. Pezzutto, J. M. Zijlstra, E. V. D. Neste, P. J. Lugtenburg, J. K. Doorduijn, M. V. Gelder, G. W. van Imhoff, F. Zettl, F. Braulke, M. Nickelsen, B. Glass, A. Rosenwald, P. Gaulard, M. Loeffler, M. Pfreundschuh, N. Schmitz, L. Trumper
Date Published: 10th May 2020
Publication Type: Journal article
Human Diseases: lymphoma, peripheral T-cell lymphoma
Abstract (Expand)
Authors: Marcus Wagner, Sarah Reinke, René Hänsel, Wolfram Klapper, Ulf-Dietrich Braumann
Date Published: 12th Mar 2020
Publication Type: Journal article
Human Diseases: diffuse large B-cell lymphoma
Abstract (Expand)
Authors: Xin Yang, Goska Leslie, Alicja Doroszuk, Sandra Schneider, Jamie Allen, Brennan Decker, Alison M. Dunning, James Redman, James Scarth, Inga Plaskocinska, Craig Luccarini, Mitul Shah, Karen Pooley, Leila Dorling, Andrew Lee, Muriel A. Adank, Julian Adlard, Kristiina Aittomäki, Irene L. Andrulis, Peter Ang, Julian Barwell, Jonine L. Bernstein, Kristie Bobolis, Åke Borg, Carl Blomqvist, Kathleen B. M. Claes, Patrick Concannon, Adeline Cuggia, Julie O. Culver, Francesca Damiola, Antoine de Pauw, Orland Diez, Jill S. Dolinsky, Susan M. Domchek, Christoph Engel, D. Gareth Evans, Florentia Fostira, Judy Garber, Lisa Golmard, Ellen L. Goode, Stephen B. Gruber, Eric Hahnen, Christopher Hake, Tuomas Heikkinen, Judith E. Hurley, Ramunas Janavicius, Zdenek Kleibl, Petra Kleiblova, Irene Konstantopoulou, Anders Kvist, Holly Laduca, Ann S. G. Lee, Fabienne Lesueur, Eamonn R. Maher, Arto Mannermaa, Siranoush Manoukian, Rachel McFarland, Wendy McKinnon, Alfons Meindl, Kelly Metcalfe, Nur Aishah Mohd Taib, Jukka Moilanen, Katherine L. Nathanson, Susan Neuhausen, Pei Sze Ng, Tu Nguyen-Dumont, Sarah M. Nielsen, Florian Obermair, Kenneth Offit, Olufunmilayo I. Olopade, Laura Ottini, Judith Penkert, Katri Pylkäs, Paolo Radice, Susan J. Ramus, Vilius Rudaitis, Lucy Side, Rachel Silva-Smith, Valentina Silvestri, Anne-Bine Skytte, Thomas Slavin, Jana Soukupova, Carlo Tondini, Alison H. Trainer, Gary Unzeitig, Lydia Usha, Thomas van Overeem Hansen, James Whitworth, Marie Wood, Cheng Har Yip, Sook-Yee Yoon, Amal Yussuf, George Zogopoulos, David Goldgar, John L. Hopper, Georgia Chenevix-Trench, Paul Pharoah, Sophia H. L. George, Judith Balmaña, Claude Houdayer, Paul James, Zaki El-Haffaf, Hans Ehrencrona, Marketa Janatova, Paolo Peterlongo, Heli Nevanlinna, Rita Schmutzler, Soo-Hwang Teo, Mark Robson, Tuya Pal, Fergus Couch, Jeffrey N. Weitzel, Aaron Elliott, Melissa Southey, Robert Winqvist, Douglas F. Easton, William D. Foulkes, Antonis C. Antoniou, Marc Tischkowitz
Date Published: 1st Mar 2020
Publication Type: Journal article
Human Diseases: hereditary breast ovarian cancer syndrome
A dataset with information on cancer history, mutation status and surveillance history for more than 100 000 study patients is provided in i2b2 (Informatics for Integrating Biology and the Bedside, http://www.i2b2.org/software). Members of the German Consortium for Hereditary Breast and Ovarian Cancer can request access to i2b2 and will be able to perform database queries independently, e.g. with regard to identify suitable patient populations for scientific evaluation projects.
Creators: Silke Zachariae, Christoph Engel
Submitter: René Hänsel
Data file type: Clinical Data
Human Diseases: hereditary breast ovarian cancer syndrome
External Link
Download
Creator: René Hänsel
Submitter: René Hänsel
Data file type: ODM Data
Human Diseases: peripheral T-cell lymphoma
Creator: René Hänsel
Submitter: René Hänsel
Data file type: Clinical Data
Human Diseases: peripheral T-cell lymphoma
Creator: René Hänsel
Submitter: René Hänsel
Data file type: Clinical Data
Human Diseases: peripheral T-cell lymphoma
Creator: René Hänsel
Submitter: René Hänsel
Data file type: ODM Data
Human Diseases: peripheral T-cell lymphoma
Age-stratified numbers of COVID-19 testpositives and deaths
This work was done as part of the NFDI4Health Task Force COVID-19 (nfdi4health.de). We gratefully acknowledge the financial support of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project Number 451265285.
Creators: René Hänsel, Holger Kirsten
Submitter: René Hänsel
Model type: Graphical model
Model format: R package
Environment: Shiny
oposSOM is a comprehensive, machine learning based open-source data analysis software combining functionalities such as diversity analyses, biomarker selection, function mining, and visualization. These functionalities are now available as interactive web-browser application for a broader user audience interested in extracting detailed information from high-throughput omics data sets pre-processed by oposSOM. It enables interactive browsing of single-gene and gene set profiles, of molecular ...
Creator: Henry Löffler-Wirth
Submitter: René Hänsel
Model type: Self-Organizing Map
Model format: R package
Environment: Shiny
All studies and research projects those data are hosted by the Leipzig Health Atlas should follow the FAIR standard. Thus, data are findable, accessible, interoperable, and reusable. To follow the FAIR standard, all data need to be described by rich metadata, on the technical and semantical level. These metadata can then be used to query and search for data elements in a single study or over all studies.
We provide the LHA data portal allowing to searching and accessing data elements in single ...
Creator: Toralf Kirsten
Submitter: René Hänsel
Model type: Not specified
Model format: Not specified
Environment: Not specified
View contentThis is an interactive version of figure 4 of the publication „Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood“.
Creator: Markus Scholz
Submitter: René Hänsel
Model type: Not specified
Model format: R package
Environment: Not specified
Implementation of recently developed dynamic mathematical models of normal and leukemic hematopoiesis to practically impact clinical decision- making.
Fitting available individual patients information, prediction of next-cycle thrombopenia caused by CHOEP treatment based on the individual fits of the preceeding treatment cycles, changing next-cycle relative dosing, posponement of the next cycle, changing follow-up period, visualization of data and simulation
Creator: Markus Scholz
Submitter: René Hänsel
Model type: Not specified
Model format: R package
Environment: Not specified
Emerging health geography research analyzes and visualizes health behaviors and outcomes in relation to urban environmental data and related official statistics to produce “health reports” for specific areas. This can be extended to developments in urban planning, e.g., to identify districts or neighborhoods for social investments or restrictions.
We mapped anthropometric data the large LIFE Adult population (10,000 participants) onto the Leipzig map. In particular, we derived the body mass index ...
Creator: Ying-Chi Lin
Submitter: René Hänsel
Model type: Not specified
Model format: Not specified
Environment: Not specified
Introduction On this homepage we provide a web-based tool to calculate prognostic scores on haematopoietic toxicity for 6 cycles CHOP-like regimen in patients with aggressive NHL. As we used for this analysis the data collected within the NHL-B1 and NHL-B2 trials of the DSHNHL as described in detail in Pfreundschuh et al. the predictions are valid for similar patient populations.
Description We offer two types of models. Pre-treatment models include beside the therapy regimen only prognostic ...
Creator: Marita Ziepert
Submitter: René Hänsel
Model type: Not specified
Model format: Not specified
Environment: Not specified
This is a set of MATLAB procedures for automated segmentation and counting of macrophages in multiple IHC stained tissue samples. Execution assumes that three aligned single-channel greyscale images of a given tissue area are available, representing IHC stainings with CD14 and CD163 antibodies (targeting macrophages) as well as DAPI staining (targeting cell cores). After detection of evaluation subregion (based on DAPI channel information), IHC stained macrophages will be masked and counted (based ...
Creators: René Hänsel, Marcus Wagner
Submitter: René Hänsel
Model type: Not specified
Model format: Matlab package
Environment: Matlab
Large scale epidemiological studies, such as LIFE-ADULT, including thousands of participants with a multitude of novel QT assessments allow to define reference values. Reference values are typically used in quality control to find outliers in a specified data volume or to evaluate a given measurement value regarding its pathologic value. Measuring the hand grip strength is a standard assessment in LIFE, for which is no or little prior knowledge regarding reference values available.
Based on the ...
Creator: Toralf Kirsten
Submitter: René Hänsel
Model type: Not specified
Model format: R package
Environment: Not specified
Emerging health geography research analyzes and visualizes health behaviors and outcomes in relation to urban environmental data and related official statistics to produce “health reports” for specific areas.
We mapped measured hand grip data of the large LIFE Adult population (10,000 participants) onto the Leipzig map. In particular, we locate each participant at the time of participation in Leipzig and, thus, can derive hand grip strength averages (incl. mean, median) per specific city districts. ...
Creator: Toralf Kirsten
Submitter: René Hänsel
Model type: Not specified
Model format: Not specified
Environment: Not specified
The publication of research results is part of good scientific practice and is increasingly ex-pected and demanded. The FAIR data principles of data sharing are an important guideline - even if medical data sharing makes it necessary to define access restrictions.
Creators: Christoph Beger, Frank A. Meineke, René Hänsel
Submitter: Christoph Beger
The Leipzig Health Atlas (LHA) offers a platform for presentation and exchange of publications, (bio-) medical data, models and software tools from the field of health research. The LHA is based on the FAIR Data Principles (Findable, Accessible, Interoperable, Reusable). Currently, more than 18 research consortia contribute data from the domains lymphoma, glioma, sepsis, hereditary colorectal and breast cancer, and others. Target groups are clinicians, epidemiologists, molecular geneticists, human ...
Creators: Christoph Beger, Frank A. Meineke, René Hänsel
Submitter: Christoph Beger
The need to manage research data is recognised by the research community - sponsors, legislators, publishers expect and encourage good scientific practice, which not only includes archiving, but also the availability of research data and results in line with FAIR principles. The publication gives a brief overview of the Leipzig Health Atlas (LHA), which is a project for the presentation and exchange of a wide range of publications, (bio) medical data (e.g. clinical, epidemiological, molecular), ...
Creators: Christoph Beger, Sebastian Stäubert, Matthias Löbe, René Hänsel
Submitter: Christoph Beger
The need to manage research data is recognised by the research community - sponsors, legislators, publishers expect and encourage good scientific practice, which not only includes archiving, but also the availability of research data and results in line with FAIR principles. The publication gives a brief overview of the Leipzig Health Atlas (LHA), which is a project for the presentation and exchange of a wide range of publications, (bio) medical data (e.g. clinical, epidemiological, molecular), ...
Creators: Christoph Beger, Sebastian Stäubert, Matthias Löbe, René Hänsel
Submitter: Christoph Beger
Diabetes screening strategies using glycated haemoglobin (HbA1c) as first-instance diagnostic parameter may cause failure to detect individuals with abnormal glucose regulation and possible signs of microvascular complications despite “rule-out” HbA1c levels. This cross-sectional study examined the diagnostic performance of HbA1c in relation to fasting and two-hour postload plasma glucose (FPG/2 h-PG), and investigated whether individuals with normal HbA1c but abnormal FPG/2 h-PG have a higher ...
Creator: Christoph Engel
Submitter: René Hänsel
Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)
Creator: Janne Pott
Submitter: René Hänsel
The medical informatics initiative was created to close the gap between research and healthcare. All of Germany’s university hospitals have joined forces with research institutions, businesses, health insurers, and patient advocacy groups to create a framework that harnesses research findings to the direct benefit of patients. The German Federal Ministry of Education and Research (BMBF) is investing around 160 million euros in the programme through 2021. The digitisation of medicine is creating ...
Projects: SMITH - Smart Medical Information Technology for Healthcare, POLAR - Polypharmacy, Drug Interactions, Risks
This is the Programme users can request to have a Project created and associated with, without the need to create and manage their own.
Projects: e:Med
Web page: Not specified
Projects: LIFE - Leipzig Research Center for Civilization Diseases, LIFE Heart, SepNet - German Competence Network Sepsis, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, COVID-19 Leipzig, LIFE Adult, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer
Web page: Not specified
Projects: HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia, GLA - German Lymphoma Alliance
Web page: Not specified
