In critical illness, a significant reduction in mortality was recently achieved by strict glycemic control, however it has to be determined whether this is true and safe for patients with sepsis as well.
As an interdisciplinary network of scientists, the SepNet study group deals with the topics of severe sepsis and septic shock. The aim of the network is to create the prerequisites for better clinical and experimental research into sepsis and thus to develop efficient treatment approaches.
Programme: LIFE Management Cluster
LHA ID: 7RY60E95M5-1
Funding codes:- Novo Nordisk
- HemoCue
- B. Braun
- Federal Ministry of Education and Research (BMBF) FKZ 01 KI 0106
Public web page: https://www.sepsis-stiftung.eu/sepnet/
Human Diseases: Disease by infectious agent
Health Atlas - Local Data Hub/Leipzig PALs: Konrad Reinhart
Project Coordinators: No Project coordinators for this Project
Project start date: 1st Jan 2003
Related items
- Institutions (3)
- Investigations (4)
- Studies (4)
- Resources (8)
- Publications (21)
- Data files (35)
- People (5)
- Programmes (1)
- Human Diseases (1)
Severe sepsis and septic shock have a high mortality. Research has concentrated on adjunctive sepsis therapies; the role of supportive measures is comparatively unclear. In Europe the use of colloids is widespread, but there is no evidence on the role of either crystalloid or colloid volume therapy in sepsis. Recently, a higher incidence of kidney failure in sepsis was reported after administration of colloids.
Snapshots: No snapshots
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Baseline Data and Endpoints for MAXSEP
Submitter: René Hänsel
Investigation: MAXSEP
Resources: MAXSEP Trial Data, MAXSEP Trial Metadata
Study type: Not specified
Snapshots: No snapshots
Baseline Data and Endpoints for HYPRESS
Submitter: Christoph Beger
Investigation: HYPRESS
Resources: HYPRESS Trial Data, HYPRESS Trial Metadata
Study type: Not specified
Snapshots: No snapshots
Baseline Data and Endpoints for SISPCT
Submitter: René Hänsel
Investigation: SISPCT
Resources: SISPCT Trail Data, SISPCT Trail Metadata
Study type: Not specified
Snapshots: No snapshots
Baseline Data and Endpoints for VISEP
Submitter: René Hänsel
Investigation: Efficacy of Volume Substitution and Insulin The...
Resources: VISEP metadata, VISEP trial data
Study type: Not specified
Snapshots: No snapshots
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: SISPCT
Study: SISPCT
Human Diseases: disease by infectious agent
Data files: SISPCT Metadata, SISPCT Metadata-ODM
Snapshots: No snapshots
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: SISPCT
Study: SISPCT
Human Diseases: disease by infectious agent
Data files: SISPCT, SISPCT-ODM, SISPCT-SPSS
Snapshots: No snapshots
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: MAXSEP
Study: MAXSEP
Human Diseases: disease by infectious agent
Data files: MAXSEP Metadata, MAXSEP Metadata-ODM
Snapshots: No snapshots
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: MAXSEP
Study: MAXSEP
Human Diseases: disease by infectious agent
Data files: MAXSEP, MAXSEP-ODM, MAXSEP-SPSS
Snapshots: No snapshots
The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids. We compared intensive insulin therapy with conventional insulin therapy and HES with Ringer’s lactate.
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: Efficacy of Volume Substitution and Insulin The...
Study: VISEP
Human Diseases: disease by infectious agent
Data files: VISEP Endpoint, VISEP Endpoint-ODM, VISEP Endpoint-SPSS, VISEP V-PAT, VISEP V-PAT-ODM, VISEP V-PAT-SPSS, VISEP V-VERL-join, VISEP V-VERL-join-ODM, VISEP V-VERL-join-SPSS, VISEP haemo_join, VISEP haemo_join-ODM, VISEP haemo_join-SPSS
Snapshots: No snapshots
The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids. We compared intensive insulin therapy with conventional insulin therapy and HES with Ringer’s lactate.
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: Efficacy of Volume Substitution and Insulin The...
Study: VISEP
Human Diseases: disease by infectious agent
Data files: VISEP Endpoint Metadata, VISEP Endpoint Metadata-ODM, VISEP V-PAT Metadata, VISEP V-PAT Metadata-ODM, VISEP V-VERL-join Metadata, VISEP V-VERL-join Metadata-ODM, VISEP haemo_join Metadata, VISEP haemo_join Metadata-ODM
Snapshots: No snapshots
Adjunctive hydrocortisone (HC) therapy is suggested by the Surviving Sepsis Campaign in refractory septic shock only. The case for septic patients without shock remains controversial. We investigated the efficacy of HC in patients with severe sepsis without shock
Restricted Trial Data
Submitter: Christoph Beger
Resource type: Result Dataset of Clinical Study
Technology type: Technology Type
Investigation: HYPRESS
Study: HYPRESS
Human Diseases: disease by infectious agent
Data files: HYPRESS Trial Data (Excel), HYPRESS Trial Data (SPSS), Hypress Trial Data (ODM)
Snapshots: No snapshots
Submitter: Christoph Beger
Resource type: Result Dataset of Clinical Study
Technology type: Technology Type
Investigation: HYPRESS
Study: HYPRESS
Human Diseases: disease by infectious agent
Data files: HYPRESS Trial Metadata (Excel), HYPRESS Trial Metadata (ODM)
Snapshots: No snapshots
Abstract (Expand)
Authors: Frank Bloos, Hendrik Rüddel, Daniel Thomas-Rüddel, Daniel Schwarzkopf, Christine Pausch, Stephan Harbarth, Torsten Schreiber, Matthias Gründling, John Marshall, Philipp Simon, Mitchell M. Levy, Manfred Weiss, Andreas Weyland, Herwig Gerlach, Tobias Schürholz, Christoph Engel, Claudia Matthäus-Krämer, Christian Scheer, Friedhelm Bach, Reimer Riessen, Bernhard Poidinger, Karin Dey, Norbert Weiler, Andreas Meier-Hellmann, Helene H. Häberle, Gabriele Wöbker, Udo X. Kaisers, Konrad Reinhart
Date Published: 1st Nov 2017
Publication Type: Journal article
Human Diseases: disease by infectious agent
DOI: 10.1007/s00134-017-4782-4
Citation: Intensive Care Med 43(11):1602-1612
Abstract (Expand)
Authors: Dirk Schädler, Christine Pausch, Daniel Heise, Andreas Meier-Hellmann, Jörg Brederlau, Norbert Weiler, Gernot Marx, Christian Putensen, Claudia Spies, Achim Jörres, Michael Quintel, Christoph Engel, John A. Kellum, Martin K. Kuhlmann
Date Published: 30th Oct 2017
Publication Type: Journal article
Human Diseases: disease by infectious agent
DOI: 10.1371/journal.pone.0187015
Citation: PLoS ONE 12(10):e0187015
Abstract (Expand)
Authors: D. Keh, E. Trips, G. Marx, S. P. Wirtz, E. Abduljawwad, S. Bercker, H. Bogatsch, J. Briegel, C. Engel, H. Gerlach, A. Goldmann, S. O. Kuhn, L. Huter, A. Meier-Hellmann, A. Nierhaus, S. Kluge, J. Lehmke, M. Loeffler, M. Oppert, K. Resener, D. Schadler, T. Schuerholz, P. Simon, N. Weiler, A. Weyland, K. Reinhart, F. M. Brunkhorst
Date Published: 1st Nov 2016
Publication Type: Journal article
Human Diseases: disease by infectious agent
PubMed ID: 27695824
Citation: JAMA. 2016 Nov 1;316(17):1775-1785. doi: 10.1001/jama.2016.14799.
Abstract (Expand)
Editor:
Date Published: 1st Oct 2016
Publication Type: Journal article
Human Diseases: disease by infectious agent
PubMed ID: 27686355
DOI: 10.1007/s00134-016-4504-3
Citation: Intensive Care Med. 2016 Dec;42(12):1980-1989. doi: 10.1007/s00134-016-4504-3. Epub 2016 Sep 29.
Abstract (Expand)
Authors: F. Bloos, E. Trips, A. Nierhaus, J. Briegel, D. K. Heyland, U. Jaschinski, O. Moerer, A. Weyland, G. Marx, M. Grundling, S. Kluge, I. Kaufmann, K. Ott, M. Quintel, F. Jelschen, P. Meybohm, S. Rademacher, A. Meier-Hellmann, S. Utzolino, U. X. Kaisers, C. Putensen, G. Elke, M. Ragaller, H. Gerlach, K. Ludewig, M. Kiehntopf, H. Bogatsch, C. Engel, F. M. Brunkhorst, M. Loeffler, K. Reinhart
Date Published: 1st Sep 2016
Publication Type: Journal article
Human Diseases: disease by infectious agent
PubMed ID: 27428731
Citation: JAMA Intern Med. 2016 Sep 1;176(9):1266-76. doi: 10.1001/jamainternmed.2016.2514.
Abstract (Expand)
Authors: Martin E. Richter, Sophie Neugebauer, Falco Engelmann, Stefan Hagel, Katrin Ludewig, Paul La Rosée, Herbert G. Sayer, Andreas Hochhaus, Marie von Lilienfeld-Toal, Tom Bretschneider, Christine Pausch, Christoph Engel, Frank M. Brunkhorst, Michael Kiehntopf
Date Published: 1st Apr 2016
Publication Type: Journal article
Human Diseases: disease by infectious agent
DOI: 10.1007/s15010-015-0830-6
Citation: Infection 44(2):175-186
Abstract (Expand)
Authors: Konrad Schmidt, Paul Thiel, Friederike Mueller, Katja Schmuecker, Susanne Worrack, Juliane Mehlhorn, Christoph Engel, Katja Brenk-Franz, Stephan Kausche, Ursula Jakobi, Anne Bindara-Klippel, Nico Schneider, Antje Freytag, Dimitry Davydow, Michel Wensing, Frank Martin Brunkhorst, Jochen Gensichen
Date Published: 1st Dec 2014
Publication Type: Journal article
Human Diseases: disease by infectious agent
Citation: Trials 15(1),283
Abstract (Expand)
Authors: F. Bloos, D. Thomas-Ruddel, H. Ruddel, C. Engel, D. Schwarzkopf, J. C. Marshall, S. Harbarth, P. Simon, R. Riessen, D. Keh, K. Dey, M. Weiss, S. Toussaint, D. Schadler, A. Weyland, M. Ragaller, K. Schwarzkopf, J. Eiche, G. Kuhnle, H. Hoyer, C. Hartog, U. Kaisers, K. Reinhart
Date Published: 3rd Mar 2014
Publication Type: Not specified
Human Diseases: bacterial infectious disease
PubMed ID: 24589043
Citation: Crit Care. 2014 Mar 3;18(2):R42. doi: 10.1186/cc13755.
Abstract (Expand)
Authors: S. Hagel, T. Bruns, M. W. Pletz, C. Engel, R. Kalff, C. Ewald
DOI: 10.1155/2014/708531
Citation: Interdisciplinary Perspectives on Infectious Diseases 2014:1-6
Abstract (Expand)
Authors: G. Elke, E. Kuhnt, M. Ragaller, D. Schadler, I. Frerichs, F. M. Brunkhorst, M. Loffler, K. Reinhart, N. Weiler
Date Published: 5th Mar 2013
Publication Type: Not specified
Human Diseases: disease by infectious agent
PubMed ID: 23455443
Citation: Med Klin Intensivmed Notfmed. 2013 Apr;108(3):223-33. doi: 10.1007/s00063-013-0224-4. Epub 2013 Mar 3.
Investigations: Efficacy of Volume Substitution and Insulin The...
Studies: VISEP
Resources: VISEP trial data
Investigations: Efficacy of Volume Substitution and Insulin The...
Studies: VISEP
Resources: VISEP trial data
Investigations: Efficacy of Volume Substitution and Insulin The...
Studies: VISEP
Resources: VISEP trial data
Investigations: Efficacy of Volume Substitution and Insulin The...
Studies: VISEP
Resources: VISEP trial data
Investigations: Efficacy of Volume Substitution and Insulin The...
Studies: VISEP
Resources: VISEP trial data
Investigations: Efficacy of Volume Substitution and Insulin The...
Studies: VISEP
Resources: VISEP trial data
Projects: LHA - Leipzig Health Atlas, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, LIFE Heart, MMML - Molecular mechanisms in malignant lymphoma, GLA - German Lymphoma Alliance, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, e:Med, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, MMML-MYC-SYS, NLP4CR - Natural Language Processing for Clinical Research, Genetical Statistics and Systems Biology, SepNet - German Competence Network Sepsis, LIFE Child, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, GGN - German Glioma Network, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, CapSys - Systems Medicine of Community Acquired Pneumonia, ProstataCA, HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia, SMITH - Smart Medical Information Technology for Healthcare, Task Force COVID-19 Leipzig, NFDI4Health, POLAR - Polypharmacy, Drug Interactions, Risks, Management of health information systems, LivSys Transfer - Transfer of the LivSys in vitro system for hepatotoxicity into application, Project Test Demonstrator, Fundus photography as tool for analysis of eyes of subjects with diabetes, Clinical Trials Leipzig, NFDI4Health - TA3 Services, STOP-NUC, SCALE-TORT
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
https://orcid.org/0000-0001-8344-0658Roles: Technician
Expertise: Data Management, Data analysis, Python, Html
Projects: LHA - Leipzig Health Atlas, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, MMML - Molecular mechanisms in malignant lymphoma, GLA - German Lymphoma Alliance, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, MMML-MYC-SYS, Genetical Statistics and Systems Biology, SepNet - German Competence Network Sepsis, HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia, e:Med, SMITH - Smart Medical Information Technology for Healthcare, Task Force COVID-19 Leipzig, NFDI4Health, POLAR - Polypharmacy, Drug Interactions, Risks
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig
Prof. Dr. Markus Löffler Universität Leipzig Institut für Medizinische Informatik, Statistik und Epidemiologie Härtelstraße 16-18 04107 Leipzig
Projects: LIFE Heart, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, SepNet - German Competence Network Sepsis, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, LIFE Child, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, LIFE Adult
Web page: https://www.uniklinikum-leipzig.de/einrichtungen/life
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_0050117
Synonyms: infectious disease
Definitions: A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.