LIFE Heart
OverviewThe LIFE-Heart study recruited 7,000 patients with suspected coronary heart disease, manifest heart disease or myocardial infarction. All patients received coronary angiography so that the vascular status in the heart is precisely known. In principle, this examination is not feasible in population-related studies. In addition, the patients were thoroughly examined with regard to the general vascular status and the health of the cardiovascular system. Extensive environmental factors were recorded. The cohort is also deeply molecularly and laboratory-medically characterized. These investigations are identical to those in LIFE-Adult, so that there are extensive possibilities for comparison between the cohorts. The LIFE-Heart study is the largest coronary angiographically characterized cohort in Germany and one of the largest worldwide.
Programme: Epidemiology
LHA-ID: 7Q0AQTKU2T-9
Funding codes:- EFRE
Public web page: http://life.uni-leipzig.de/
Organisms: Homo sapiens
Human Diseases: Cardiovascular system disease
Leipzig Health Atlas PALs: No PALs for this Project
Project start date: 1st Jan 2009
Related items
Projects: Leipzig Health Atlas, German Consortium for Hereditary Breast and Ovarian Cancer, LIFE- Leipzig Research Center for Civilization Diseases, LIFE Adult, German Lymphoma Alliance (GLA), LIFE Head and Neck Cancer Group, Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, Genetical Statistics and Systems Biology, Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, German Consortium for Hereditary Non-Polyposis Colorectal Cancer, German Glioma Network, German Competence Network Sepsis (SepNet), Natural Language Processing for Clinical Research, LIFE Heart, Molecular mechanisms in malignant lymphoma, Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, LIFE Child, MMML-MYC-SYS, ProstataCA, COVID-19 Leipzig
Institutions: Institute for Medical Informatics, Statistics and Epidemiology
https://orcid.org/0000-0001-8344-0658
Markus Scholz
Scientific Speaker Institution
Institut für Medizinische Informatik, Statistik und Epidemiologie
Universität Leipzig
Härtelstraße 16-18
04107 Leipzig
Resutls of different OMICS-level using LIFE Adult and LIFE Heart data are presented (Publications, Supplemental Data, & Summary Statistics).
Snapshots: No snapshots
We analysed if measuring PWV in different segments of the body leads to association with different genetic variants, as well as different heritability and different genetic correlation with other biological traits. Furthermore we searched for shared genetic architecture concerning PWV, blood pressure (BP) and coronary artery disease (CAD) and examined the causal relationship between PWV and BP.
We defined six operationalizations of CPB considering plaques in common carotid arteries, carotid bulb, and internal carotid arteries (maximal plaque area, mean plaque area, sum of plaque areas at all six regions, maximal degree of stenosis, mean degree of stenosis, and sum of stenosis at all six regions).
Link to publication (PMID, DOI), Supplemental Figures and Tables, and Summary Statistics of GWAS will be made available upon acceptance of our manuscript.
Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)
Summary statistics from GWAS of baPWV, bfPWV, cfPWV
All samples (adjusted for age, sex and log_sys)
These data is intended for research purposes only.
Citation: tbc
When using this data acknowledge the source as follows: 'Data on PWV has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/34'
For any enquiries about the datasets, please contact Michael Rode (michael.rode@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de)
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Submitter: Michael Rode
Assay type: Genome Wide Association
Technology type: SNP Array
Snapshots: No snapshots
We are releasing the summary data from our GWAS of carotid plaque burden traits, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.
Citation:
When using this data acknowledge the source as follows: 'Data on carotid plaque burden has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/31 '
For any
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Submitter: Janne Pott
Assay type: Genome Wide Association
Technology type: SNP Array
Snapshots: No snapshots
We are releasing the summary data from our meta-analyses of steroid hormones, to empower other researchers to examine variants or loci in which they are interested for association with these hormonal traits. These data are intended for research purposes only.
Citation:
Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge
...
Submitter: Janne Pott
Assay type: Genome Wide Association
Technology type: SNP Array
Snapshots: No snapshots
The primary goal of this study was to identify genetic loci associated with steroid hormone levels (cortisol, DHEA-S, testosterone, estradiol, progesterone, 17-hydroxyprogesterone, androstenedione, and aldosterone). In a secondary analysis, we searched for causal effects of steroid hormones on coronary artery disease.
Submitter: René Hänsel
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
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Abstract (Expand)
Authors: J. Pott, YJ. Bae, K. Horn, A. Teren, Andreas Kühnapfel, H. Kirsten, U. Ceglarek, Markus Löffler, J. Thiery, J. Kratzsch, Markus Scholz
Date Published: 6th Jun 2019
Publication Type: Not specified
Human Diseases: coronary artery disease
Abstract (Expand)
Authors: S. Zewinger, M. E. Kleber, V. Tragante, R. O. McCubrey, A. F. Schmidt, K. Direk, U. Laufs, C. Werner, W. Koenig, D. Rothenbacher, U. Mons, L. P. Breitling, H. Brenner, R. T. Jennings, I. Petrakis, S. Triem, M. Klug, A. Filips, S. Blankenberg, C. Waldeyer, C. Sinning, R. B. Schnabel, K. J. Lackner, E. Vlachopoulou, O. Nygard, G. F. T. Svingen, E. R. Pedersen, G. S. Tell, J. Sinisalo, M. S. Nieminen, R. Laaksonen, S. Trompet, R. A. J. Smit, N. Sattar, J. W. Jukema, H. V. Groesdonk, G. Delgado, T. Stojakovic, A. P. Pilbrow, V. A. Cameron, A. M. Richards, R. N. Doughty, Y. Gong, R. Cooper-DeHoff, J. Johnson, M. Scholz, F. Beutner, J. Thiery, J. G. Smith, R. O. Vilmundarson, R. McPherson, A. F. R. Stewart, S. Cresci, P. A. Lenzini, J. A. Spertus, O. Olivieri, D. Girelli, N. I. Martinelli, A. Leiherer, C. H. Saely, H. Drexel, A. Mundlein, P. S. Braund, C. P. Nelson, N. J. Samani, D. Kofink, I. E. Hoefer, G. Pasterkamp, A. A. Quyyumi, Y. A. Ko, J. A. Hartiala, H. Allayee, W. H. W. Tang, S. L. Hazen, N. Eriksson, C. Held, E. Hagstrom, L. Wallentin, A. Akerblom, A. Siegbahn, I. Karp, C. Labos, L. Pilote, J. C. Engert, J. M. Brophy, G. Thanassoulis, P. Bogaty, W. Szczeklik, M. Kaczor, M. Sanak, S. S. Virani, C. M. Ballantyne, V. V. Lee, E. Boerwinkle, M. V. Holmes, B. D. Horne, A. Hingorani, F. W. Asselbergs, R. S. Patel, B. K. Kramer, H. Scharnagl, D. Fliser, W. Marz, T. Speer
Date Published: 2nd Jun 2017
Publication Type: Journal
Abstract (Expand)
Authors: A. Teren, H. Kirsten, F. Beutner, M. Scholz, L. M. Holdt, D. Teupser, M. Gutberlet, J. Thiery, G. Schuler, I. Eitel
Abstract (Expand)
Authors: C. Loley, M. Alver, T. L. Assimes, A. Bjonnes, A. Goel, S. Gustafsson, J. Hernesniemi, J. C. Hopewell, S. Kanoni, M. E. Kleber, K. W. Lau, Y. Lu, L. P. Lyytikainen, C. P. Nelson, M. Nikpay, L. Qu, E. Salfati, M. Scholz, T. Tukiainen, C. Willenborg, H. H. Won, L. Zeng, W. Zhang, S. S. Anand, F. Beutner, E. P. Bottinger, R. Clarke, G. Dedoussis, R. Do, T. Esko, M. Eskola, M. Farrall, D. Gauguier, V. Giedraitis, C. B. Granger, A. S. Hall, A. Hamsten, S. L. Hazen, J. Huang, M. Kahonen, T. Kyriakou, R. Laaksonen, L. Lind, C. Lindgren, P. K. Magnusson, E. Marouli, E. Mihailov, A. P. Morris, K. Nikus, N. Pedersen, L. Rallidis, V. Salomaa, S. H. Shah, A. F. Stewart, J. R. Thompson, P. A. Zalloua, J. C. Chambers, R. Collins, E. Ingelsson, C. Iribarren, P. J. Karhunen, J. S. Kooner, T. Lehtimaki, R. J. Loos, W. Marz, R. McPherson, A. Metspalu, M. P. Reilly, S. Ripatti, D. K. Sanghera, J. Thiery, H. Watkins, P. Deloukas, S. Kathiresan, N. J. Samani, H. Schunkert, J. Erdmann, I. R. Konig
Abstract
Authors: M. Vausort, A. Salgado-Somoza, L. Zhang, P. Leszek, M. Scholz, A. Teren, R. Burkhardt, J. Thiery, D. R. Wagner, Y. Devaux
Date Published: 13th Sep 2016
Publication Type: Journal
Human Diseases: left ventricular noncompaction, myocardial infarction
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_1287
Synonyms: disease of subdivision of hemolymphoid system
Definitions: A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)
Creator: Janne Pott
Submitter: René Hänsel
