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The aim of LIFE ADULT is to find out more about common diseases such as cancer, diabetes or cardiovascular diseases. In Germany, many people are affected by these diseases - and more are being diagnosed every day. The everyday life and quality of life of those affected, but also of their relatives, are often severely impaired. With this research, this epidemiological study hopes to obtain answers to a wide variety of questions.
This population-based study examined 10,000 participants randomly selected from the Leipzig population (2011 to 2014). A follow-up is to be carried out from 2017 - 2020. The study mainly included people aged between 40 and 79. All participants underwent a 6-hour study program and people over 60 years of age were invited two more times to in-depth study of cognition and depression and the brain (MRI, EEG). Extensive measurements of genome, metabolome and transcriptome are available. The LIFE-ADULT study is characterized by a special depth of investigation. More than 100 evaluation projects are currently in progress.
Programme: Epidemiology
Health Atlas ID: 7Q6PJD8NV3-2
Public web page: http://life.uni-leipzig.de/en/adults/life_adult.html
Organisms: Homo sapiens
Human Diseases: Mood disorder, Dementia, Coronary artery disease, Obesity
Health Atlas PALs: Markus Löffler
Project Coordinators: Christian Sander
Project start date: 1st Jan 2009
Related items
- Institutions (5)
- Investigations (1)
- Studies (3+1)
- Resources (4+1)
- Publications (99)
- Data files (119)
- Models (4)
- Documents (2)
- People (17)
- Human Diseases (4)
Resutls of different OMICS-level using LIFE Adult and LIFE Heart data are presented (Publications, Supplemental Data, & Summary Statistics).
Snapshots: No snapshots
We analysed if measuring PWV in different segments of the body leads to association with different genetic variants, as well as different heritability and different genetic correlation with other biological traits. Furthermore we searched for shared genetic architecture concerning PWV, blood pressure (BP) and coronary artery disease (CAD) and examined the causal relationship between PWV and BP.
Investigation: OMICS Investigations
Resources: Summary Statistic for PWV GWAS
We defined six operationalizations of CPB considering plaques in common carotid arteries, carotid bulb, and internal carotid arteries (maximal plaque area, mean plaque area, sum of plaque areas at all six regions, maximal degree of stenosis, mean degree of stenosis, and sum of stenosis at all six regions).
Link to publication (PMID, DOI), Supplemental Figures and Tables, and Summary Statistics of GWAS will be made available upon acceptance of our manuscript.
Investigation: OMICS Investigations
Resources: Summary Statistics
Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)
Investigation: OMICS Investigations
Resources: Summary Statistics, Supplement Data
Summary statistics from GWAS of baPWV, bfPWV, cfPWV
All samples (adjusted for age, sex and log_sys)
These data is intended for research purposes only.
Citation: tbc
When using this data acknowledge the source as follows: 'Data on PWV has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/34'
For any enquiries about the datasets, please contact Michael Rode (michael.rode@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de)
...
Submitter: Michael Rode
Resource type: Genome Wide Association
Technology type: SNP Array
Snapshots: No snapshots
Investigation: OMICS Investigations
Study: GWAS Pulse Wave Velocity
Organisms: No organisms
Human Diseases: No human diseases
SOPs: No SOPs
Data files: PWV summary statistics
We are releasing the summary data from our GWAS of carotid plaque burden traits, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.
Citation:
When using this data acknowledge the source as follows: 'Data on carotid plaque burden has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/31 '
For any
...
Submitter: Janne Pott
Resource type: Genome Wide Association
Technology type: SNP Array
Snapshots: No snapshots
Investigation: OMICS Investigations
Study: GWAS Carotid Plaque Burden
Organisms: No organisms
Human Diseases: atherosclerosis, coronary artery disease
SOPs: No SOPs
Data files: Summary Statistics for CPA_max, Summary Statistics for CPA_mean, Summary Statistics for CPA_sum, Summary Statistics for CPS_max, Summary Statistics for CPS_mean, Summary Statistics for CPS_sum
We are releasing the summary data from our meta-analyses of steroid hormones, to empower other researchers to examine variants or loci in which they are interested for association with these hormonal traits. These data are intended for research purposes only.
Citation:
Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge
...
Submitter: Janne Pott
Resource type: Genome Wide Association
Technology type: SNP Array
Snapshots: No snapshots
Investigation: OMICS Investigations
Study: GWAS Steroid Hormones
Organisms: No organisms
Human Diseases: No human diseases
SOPs: No SOPs
Data files: Summary Statistics for 17-OH-Progesterone, Summary Statistics for Aldosterone, Summary Statistics for Androstenedione, Summary Statistics for Cortisol, Summary Statistics for DHEAS, Summary Statistics for Estradiol, Summary Statistics for Progesterone, Summary Statistics for Testosterone
The primary goal of this study was to identify genetic loci associated with steroid hormone levels (cortisol, DHEA-S, testosterone, estradiol, progesterone, 17-hydroxyprogesterone, androstenedione, and aldosterone). In a secondary analysis, we searched for causal effects of steroid hormones on coronary artery disease.
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: OMICS Investigations
Study: GWAS Steroid Hormones
Organisms: No organisms
Human Diseases: coronary artery disease
SOPs: No SOPs
Data files: GWAS_SteroidHormones_SupTables
Abstract (Expand)
Authors: M. Gorski, B. Jung, Y. Li, P. R. Matias-Garcia, M. Wuttke, S. Coassin, C. H. L. Thio, M. E. Kleber, T. W. Winkler, V. Wanner, J. F. Chai, A. Y. Chu, M. Cocca, M. F. Feitosa, S. Ghasemi, A. Hoppmann, K. Horn, M. Li, T. Nutile, M. Scholz, K. B. Sieber, A. Teumer, A. Tin, J. Wang, B. O. Tayo, T. S. Ahluwalia, P. Almgren, S. J. L. Bakker, B. Banas, N. Bansal, M. L. Biggs, E. Boerwinkle, E. P. Bottinger, H. Brenner, R. J. Carroll, J. Chalmers, M. L. Chee, M. L. Chee, C. Y. Cheng, J. Coresh, M. H. de Borst, F. Degenhardt, K. U. Eckardt, K. Endlich, A. Franke, S. Freitag-Wolf, P. Gampawar, R. T. Gansevoort, M. Ghanbari, C. Gieger, P. Hamet, K. Ho, E. Hofer, B. Holleczek, V. H. Xian Foo, N. Hutri-Kahonen, S. J. Hwang, M. A. Ikram, N. S. Josyula, M. Kahonen, C. C. Khor, W. Koenig, H. Kramer, B. K. Kramer, B. Kuhnel, L. A. Lange, T. Lehtimaki, W. Lieb, R. J. F. Loos, M. A. Lukas, L. P. Lyytikainen, C. Meisinger, T. Meitinger, O. Melander, Y. Milaneschi, P. P. Mishra, N. Mononen, J. C. Mychaleckyj, G. N. Nadkarni, M. Nauck, K. Nikus, B. Ning, I. M. Nolte, M. L. O'Donoghue, M. Orho-Melander, S. A. Pendergrass, B. W. J. H. Penninx, M. H. Preuss, B. M. Psaty, L. M. Raffield, O. T. Raitakari, R. Rettig, M. Rheinberger, K. M. Rice, A. R. Rosenkranz, P. Rossing, J. I. Rotter, C. Sabanayagam, H. Schmidt, R. Schmidt, B. Schottker, C. A. Schulz, S. Sedaghat, C. M. Shaffer, K. Strauch, S. Szymczak, K. D. Taylor, J. Tremblay, L. Chaker, P. van der Harst, P. J. van der Most, N. Verweij, U. Volker, M. Waldenberger, L. Wallentin, D. M. Waterworth, H. D. White, J. G. Wilson, T. Y. Wong, M. Woodward, Q. Yang, M. Yasuda, L. M. Yerges-Armstrong, Y. Zhang, H. Snieder, C. Wanner, C. A. Boger, A. Kottgen, F. Kronenberg, C. Pattaro, I. M. Heid
Date Published: 30th Oct 2020
Publication Type: Journal article
PubMed ID: 33137338
Citation: Kidney Int. 2020 Oct 30. pii: S0085-2538(20)31239-4. doi: 10.1016/j.kint.2020.09.030.
Abstract (Expand)
Authors: Michael Rode, Andrej Teren, Kerstin Wirkner, Katrin Horn, Holger Kirsten, Markus Loeffler, Markus Scholz, Janne Pott
Date Published: 13th Aug 2020
Publication Type: Journal article
Human Diseases: arteriosclerosis, arteriosclerotic cardiovascular disease
DOI: 10.1371/journal.pone.0237237
Citation: PLoS ONE 15(8):e0237237
Abstract (Expand)
Authors: Neda Baniasadi, Franziska G. Rauscher, Dian Li, Mengyu Wang, Eun Young Choi, Hui Wang, Thomas Peschel, Kerstin Wirkner, Toralf Kirsten, Joachim Thiery, Christoph Engel, Markus Loeffler, Tobias Elze
Date Published: 3rd Aug 2020
Publication Type: Journal article
DOI: 10.1167/tvst.9.9.23
Citation: Trans. Vis. Sci. Tech. 9(9):23
Abstract (Expand)
Authors: A. Frenzel, H. Binder, N. Walter, K. Wirkner, M. Loeffler, H. Loeffler-Wirth
Date Published: 29th Mar 2020
Publication Type: Not specified
PubMed ID: 32218988
Citation: NPJ Aging Mech Dis. 2020 Mar 24;6:5. doi: 10.1038/s41514-020-0043-9. eCollection 2020.
Abstract (Expand)
Authors: D. Li, F. G. Rauscher, E. Y. Choi, M. Wang, N. Baniasadi, K. Wirkner, T. Kirsten, J. Thiery, C. Engel, M. Loeffler, T. Elze
Date Published: 17th Nov 2019
Publication Type: Journal article
PubMed ID: 31732228
Citation: Ophthalmology. 2020 Mar;127(3):357-368. doi: 10.1016/j.ophtha.2019.09.019. Epub 2019 Sep 25.
All studies and research projects those data are hosted by the Leipzig Health Atlas should follow the FAIR standard. Thus, data are findable, accessible, interoperable, and reusable. To follow the FAIR standard, all data need to be described by rich metadata, on the technical and semantical level. These metadata can then be used to query and search for data elements in a single study or over all studies.
We provide the LHA data portal allowing to searching and accessing data elements in single
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Creator: Toralf Kirsten
Submitter: René Hänsel
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Not specified
Human Disease: Not specified
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Emerging health geography research analyzes and visualizes health behaviors and outcomes in relation to urban environmental data and related official statistics to produce “health reports” for specific areas. This can be extended to developments in urban planning, e.g., to identify districts or neighborhoods for social investments or restrictions.
We mapped anthropometric data the large LIFE Adult population (10,000 participants) onto the Leipzig map. In particular, we derived the body mass index
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Creator: Ying-Chi Lin
Submitter: René Hänsel
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Not specified
Human Disease: obesity
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Large scale epidemiological studies, such as LIFE-ADULT, including thousands of participants with a multitude of novel QT assessments allow to define reference values. Reference values are typically used in quality control to find outliers in a specified data volume or to evaluate a given measurement value regarding its pathologic value. Measuring the hand grip strength is a standard assessment in LIFE, for which is no or little prior knowledge regarding reference values available.
Based on the
...
Creator: Toralf Kirsten
Submitter: René Hänsel
Model type: Not specified
Model format: R package
Environment: Not specified
Organism: Not specified
Human Disease: Not specified
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Emerging health geography research analyzes and visualizes health behaviors and outcomes in relation to urban environmental data and related official statistics to produce “health reports” for specific areas.
We mapped measured hand grip data of the large LIFE Adult population (10,000 participants) onto the Leipzig map. In particular, we locate each participant at the time of participation in Leipzig and, thus, can derive hand grip strength averages (incl. mean, median) per specific city districts.
...
Creator: Toralf Kirsten
Submitter: René Hänsel
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Not specified
Human Disease: Not specified
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Diabetes screening strategies using glycated haemoglobin (HbA1c) as first-instance diagnostic parameter may cause failure to detect individuals with abnormal glucose regulation and possible signs of microvascular complications despite “rule-out” HbA1c levels. This cross-sectional study examined the diagnostic performance of HbA1c in relation to fasting and two-hour postload plasma glucose (FPG/2 h-PG), and investigated whether individuals with normal HbA1c but abnormal FPG/2 h-PG have a higher
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Creator: Christoph Engel
Submitter: René Hänsel
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)
Creator: Janne Pott
Submitter: René Hänsel
Projects: LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer
Institutions: Institute for Medical Informatics, Statistics and Epidemiology

Expertise: hereditary cancer, biometry, epidemiology
Projects: LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases
Institutions: University of Leipzig
Projects: LHA - Leipzig Health Atlas, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, LIFE Heart, MMML - Molecular mechanisms in malignant lymphoma, GLA - German Lymphoma Alliance, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, MMML-MYC-SYS, NLP4CR - Natural Language Processing for Clinical Research, Genetical Statistics and Systems Biology, SepNet - German Competence Network Sepsis, LIFE Child, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, GGN - German Glioma Network, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, ProstataCA, SMITH - Smart Medical Information Technology for Healthcare, COVID-19 Leipzig, Management of health information systems
Institutions: Institute for Medical Informatics, Statistics and Epidemiology

Roles: Technician
Expertise: Data Management, Data analysis, Python, Html
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_9970
Definitions: OMIM mapping confirmed by DO. [SN].
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_3393
Synonyms: Coronary disease, coronary heart disease, CHD (coronary heart disease), coronary arteriosclerosis
Definitions: Xref MGI., An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_1307
Definitions: A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_3324
Synonyms: episodic mood disorder
Definitions: Updating outdated UMLS CUI., A cognitive disorder that involves an excessive, irrational dread of everyday situations.