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disease by infectious agent

Details about this human disease

Synonyms (1)

infectious disease


Definitions (1)

A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.


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Related items

LIFE- Leipzig Research Center for Civilization Diseases

Goal of the Leipzig Research Center for Civilization Diseases (LIFE) is the investigation of civilization diseases like depression, diabetes, allergies or cardiovascular diseases. For this purpose we collect as much data as possible regarding health and living conditions of the population in Leipzig and provide these data for scientists of the University of Leipzig and other research institutions.

Programme: Epidemiology

Public web page: http://life.uni-leipzig.de/

Start date: 1st Jan 2009

Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome

CAP-Sys

Programme: This Project is not associated with a Programme

Public web page: Not specified

Start date: 1st Jan 2017

COVID-19 Leipzig

This project serves as a container for all COVID-19 related assets, developed at the University of Leipzig and its partners.

Programme: Epidemiology

Public web page: Not specified

Start date: 20th May 2020

German Competence Network Sepsis (SepNet)

As an interdisciplinary network of scientists, the SepNet study group deals with the topics of severe sepsis and septic shock. The aim of the network is to create the prerequisites for better clinical and experimental research into sepsis and thus to develop efficient treatment approaches.

Programme: Epidemiology

Public web page: https://www.sepsis-stiftung.eu/sepnet/

Start date: 1st Jan 2003

Covid-19 Data Sources worldwide
COVID-19 Leipzig
No description specified

Submitter: René Hänsel

Assay type: Experimental Assay Type

Technology type: Technology Type

Snapshots: No snapshots

Covid-19 Data Sources Germany
COVID-19 Leipzig
No description specified

Submitter: René Hänsel

Assay type: Experimental Assay Type

Technology type: Technology Type

Snapshots: No snapshots

SISPCT Trail Metadata
German Competence Network Sepsis (SepNet)
No description specified

Submitter: René Hänsel

Assay type: Experimental Assay Type

Technology type: Technology Type

Snapshots: No snapshots

SISPCT Trail Data
German Competence Network Sepsis (SepNet)
No description specified

Submitter: René Hänsel

Assay type: Experimental Assay Type

Technology type: Technology Type

Snapshots: No snapshots

MAXSEP Trial Metadata
German Competence Network Sepsis (SepNet)
No description specified

Submitter: René Hänsel

Assay type: Experimental Assay Type

Technology type: Technology Type

Snapshots: No snapshots

Covid-19 Transmission Trajectories-Monitoring the Pandemic in the Worldwide Context.
COVID-19 Leipzig

Abstract (Expand)

The Covid-19 pandemic is developing worldwide with common dynamics but also with marked differences between regions and countries. These are not completely understood, but presumably, provide a clue … to find ways to mitigate epidemics until strategies leading to its eradication become available. We describe an iteractive monitoring tool available in the internet. It enables inspection of the dynamic state of the epidemic in 187 countries using trajectories that visualize the transmission and removal rates of the epidemic and in this way bridge epi-curve tracking with modelling approaches. Examples were provided which characterize state of epidemic in different regions of the world in terms of fast and slow growing and decaying regimes and estimate associated rate factors. The basic spread of the disease is associated with transmission between two individuals every two-three days on the average. Non-pharmaceutical interventions decrease this value to up to ten days, whereas 'complete lock down' measures are required to stop the epidemic. Comparison of trajectories revealed marked differences between the countries regarding efficiency of measures taken against the epidemic. Trajectories also reveal marked country-specific recovery and death rate dynamics. The results presented refer to the pandemic state in May to July 2020 and can serve as 'working instruction' for timely monitoring using the interactive monitoring tool as a sort of 'seismometer' for the evaluation of the state of epidemic, e.g., the possible effect of measures taken in both, lock-down and lock-up directions. Comparison of trajectories between countries and regions will support developing hypotheses and models to better understand regional differences of dynamics of Covid-19.

Authors: H. Loeffler-Wirth, M. Schmidt, H. Binder

Date Published: 20th Jul 2020

Publication Type: Journal article

Human Diseases: COVID-19

Hospital-wide ELectronic medical record evaluated computerised decision support system to improve outcomes of Patients with staphylococcal bloodstream infection (HELP): study protocol for a multicentre stepped-wedge cluster randomised trial
SMITH

Abstract

Not specified

Authors: Stefan Hagel, Julia Gantner, Cord Spreckelsen, Claudia Fischer, Danny Ammon, Kutaiba Saleh, Lo An Phan-Vogtmann, Andrew Heidel, Susanne Müller, Alexander Helhorn, Henner Kruse, Eric Thomas, Florian Rißner, Silke Haferkamp, Jens Vorwerk, Saskia Deffge, Marc Fabian Juzek-Küpper, Norman Lippmann, Christoph Lübbert, Henning Trawinski, Sebastian Wendt, Thomas Wendt, Andreas Dürschmid, Margarethe Konik, Stefan Moritz, Daniel Tiller, Rainer Röhrig, Jonas Schulte-Coerne, Jonas Fortmann, Stephan Jonas, Oliver Witzke, Peter-Michael Rath, Mathias W Pletz, André Scherag

Date Published: 10th Feb 2020

Publication Type: Journal article

Human Diseases: staphyloenterotoxemia

Commentary: Arguing for Adaptive Clinical Trials in Sepsis
SMITH

Abstract

Not specified

Authors: Miriam Kesselmeier, André Scherag

Date Published: 30th Oct 2018

Publication Type: Journal article

Human Diseases: disease by infectious agent

Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome.
Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome

Abstract (Expand)

We analyzed the blood transcriptome of sepsis framed within community-acquired pneumonia (CAP) and characterized its molecular and cellular heterogeneity in terms of functional modules of co-regulated … genes with impact for the underlying pathophysiological mechanisms. Our results showed that CAP severity is associated with immune suppression owing to T-cell exhaustion and HLA and chemokine receptor deactivation, endotoxin tolerance, macrophage polarization, and metabolic conversion from oxidative phosphorylation to glycolysis. We also found footprints of host's response to viruses and bacteria, altered levels of mRNA from erythrocytes and platelets indicating coagulopathy that parallel severity of sepsis and survival. Finally, our data demonstrated chromatin re-modeling associated with extensive transcriptional deregulation of chromatin modifying enzymes, which suggests the extensive changes of DNA methylation with potential impact for marker selection and functional characterization. Based on the molecular footprints identified, we propose a novel stratification of CAP cases into six groups differing in the transcriptomic scores of CAP severity, interferon response, and erythrocyte mRNA expression with impact for prognosis. Our analysis increases the resolution of transcriptomic footprints of CAP and reveals opportunities for selecting sets of transcriptomic markers with impact for translation of omics research in terms of patient stratification schemes and sets of signature genes.

Authors: L. Hopp, H. Loeffler-Wirth, L. Nersisyan, A. Arakelyan, H. Binder

Date Published: 2nd Aug 2018

Publication Type: Not specified

Human Diseases: disease by infectious agent, pneumonia

Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial
German Competence Network Sepsis (SepNet)

Abstract (Expand)

PURPOSE Guidelines recommend administering antibiotics within 1 h of sepsis recognition but this recommendation remains untested by randomized trials. This trial was set up to investigate whether …r survival is improved by reducing the time before initiation of antimicrobial therapy by means of a multifaceted intervention in compliance with guideline recommendations. METHODS The MEDUSA study, a prospective multicenter cluster-randomized trial, was conducted from July 2011 to July 2013 in 40 German hospitals. Hospitals were randomly allocated to receive conventional continuous medical education (CME) measures (control group) or multifaceted interventions including local quality improvement teams, educational outreach, audit, feedback, and reminders. We included 4183 patients with severe sepsis or septic shock in an intention-to-treat analysis comparing the multifaceted intervention (n = 2596) with conventional CME (n = 1587). The primary outcome was 28-day mortality. RESULTS The 28-day mortality was 35.1% (883 of 2596 patients) in the intervention group and 26.7% (403 of 1587 patients; p = 0.01) in the control group. The intervention was not a risk factor for mortality, since this difference was present from the beginning of the study and remained unaffected by the intervention. Median time to antimicrobial therapy was 1.5 h (interquartile range 0.1-4.9 h) in the intervention group and 2.0 h (0.4-5.9 h; p = 0.41) in the control group. The risk of death increased by 2% per hour delay of antimicrobial therapy and 1% per hour delay of source control, independent of group assignment. CONCLUSIONS Delay in antimicrobial therapy and source control was associated with increased mortality but the multifaceted approach was unable to change time to antimicrobial therapy in this setting and did not affect survival.

Authors: Frank Bloos, Hendrik Rüddel, Daniel Thomas-Rüddel, Daniel Schwarzkopf, Christine Pausch, Stephan Harbarth, Torsten Schreiber, Matthias Gründling, John Marshall, Philipp Simon, Mitchell M. Levy, Manfred Weiss, Andreas Weyland, Herwig Gerlach, Tobias Schürholz, Christoph Engel, Claudia Matthäus-Krämer, Christian Scheer, Friedhelm Bach, Reimer Riessen, Bernhard Poidinger, Karin Dey, Norbert Weiler, Andreas Meier-Hellmann, Helene H. Häberle, Gabriele Wöbker, Udo X. Kaisers, Konrad Reinhart

Date Published: 1st Nov 2017

Publication Type: Journal article

Human Diseases: disease by infectious agent

ECDC COVID-19 Data
COVID-19 Leipzig
No description specified

Creator: European Centre for Disease Prevention and Control

Submitter: René Hänsel

Data file type: Geographical Data

Human Diseases: COVID-19

External Link
JHU COVID-19 Data
COVID-19 Leipzig
No description specified

Creator: Johns Hopkins University

Submitter: René Hänsel

Data file type: Geographical Data

Human Diseases: COVID-19

External Link
RKI COVID-19 Data
COVID-19 Leipzig
No description specified

Creator: Robert Koch Institute

Submitter: René Hänsel

Data file type: Geographical Data

Human Diseases: COVID-19

External Link
RKI COVID-19 Data for German federal states
COVID-19 Leipzig

Feature service with the current Covid-19 infections per 100,000 inhabitants on the German federal states. The service is updated daily with the current case numbers of the Robert Koch Institute.

Data source: Robert Koch Institute
Terms of Use: Robert Koch Institute; German Federal Agency for Cartography and Geodesy
Source note: Robert Koch-Institute (RKI), dl-en/by-2-0 Disclaimer: "The content made available on the Internet pages of the Robert Koch-Institute is intended solely for the general
...

Creator: Robert Koch Institute

Submitter: René Hänsel

Data file type: Not specified

Human Diseases: COVID-19

External Link
RKI COVID-19 Data German districts
COVID-19 Leipzig

Feature service with the current Covid-19 infections per 100,000 inhabitants on the German districts. The service is updated daily with the current case numbers of the Robert Koch Institute.

Data source: Robert Koch Institute
Terms of Use: Robert Koch Institute; German Federal Agency for Cartography and Geodesy
Source note: Robert Koch-Institute (RKI), dl-en/by-2-0 Disclaimer: "The content made available on the Internet pages of the Robert Koch-Institute is intended solely for the general information
...

Creator: Robert Koch Institute

Submitter: René Hänsel

Data file type: Not specified

Human Diseases: COVID-19

External Link
Covid-19 Viewer
COVID-19 Leipzig

The Covid‐19 viewer provides an intuitive tool to monitor the development of the pandemic in 188 countries using simple plots. The tool is interactive and enables the user to select different plots for single countries, groups or all of them. It visualizes descriptive features such as slopes or flattening behaviour of epidemic numbers and of their increments to allow a qualitative justification of the current state of the pandemic, e.g. whether it is growing exponentially, stopped due to counter
...

Creators: Henry Löffler-Wirth, Hans Binder

Submitter: Henry Löffler-Wirth

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