Gene expression patterns and TP53 mutations are associated with HPV RNA status, lymph node metastasis, and survival in head and neck cancer (clinical Dataset) Version 2
Our first objective was to compare the molecular features of subgroups of HNSCC defined by their HPV16 DNA and RNA status. The second objective was to identify gene expression subtypes in HNSCC and to correlate them with other characteristics of the patients.
HPV DNA and RNA status, mutations of 50 genes, survival and other clinical characteristics of 270 patients with head and neck cancer.
Data file type: Clinical Data
Human Diseases: Head and neck squamous cell carcinoma
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The aim of the Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) is to facilitate improvements in the treatment and care of head and neck cancer patients through insights from molecular studies.
The Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) investigates the molecular mechanisms and the diagnostic and prognostic factors of head and neck cancer. For this purpose, we collected phenotypic information from about 300
Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status
Person responsible: Maciej Rosolowski
Snapshots: No snapshots
Study type: Clinical study (Phase 1)
Submitter: René Hänsel
Assay type: Experimental Assay Type
Technology type: Technology Type
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Authors: G. Wichmann, M. Rosolowski, K. Krohn, M. Kreuz, A. Boehm, A. Reiche, U. Scharrer, D. Halama, J. Bertolini, U. Bauer, D. Holzinger, M. Pawlita, J. Hess, C. Engel, D. Hasenclever, M. Scholz, P. Ahnert, H. Kirsten, A. Hemprich, C. Wittekind, O. Herbarth, F. Horn, A. Dietz, M. Loeffler
Date Published: 15th Dec 2015
Publication Type: Not specified
Human Diseases: head and neck cancer
PubMed ID: 26095926
Citation: Int J Cancer. 2015 Dec 15;137(12):2846-57. doi: 10.1002/ijc.29649. Epub 2015 Jul 6.
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_5520
Synonyms: squamous cell carcinoma of the head and neck, squamous cell carcinomas of head and neck, carcinoma of the head and neck
Definitions: A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck., OMIM mapping confirmed by DO. [SN].