The PREMM1,2,6 has been developed as a pretest to decide whether patients suspected of having Lynch syndrome should be tested for germline mismatch repair gene mutations.
"PREMM1,2,6" is a logistic regression model. It calculates the risk of having a mutation in the mismatch repair genes MLH1, MSH2 and MSH6 (for single genes and overall) based on the personal and familial cancer history of the proband (colorectal, endometrial, and other Lynch syndrome related cancers).
Creators: Christoph Engel, Silke Zachariae, Kastrinos et al.
Contributor: Silke Zachariae
Model type: Not specified
Model format: Not specified
Environment: Not specified
Human Disease: hereditary breast ovarian cancer syndrome
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
The PREMM5 has been developed as a pretest to decide whether patients suspected of having Lynch syndrome should be tested for germline mismatch repair gene mutations. In contrast to "PREMM1,2,6" it can be used to predict mutation probabilities in unaffected index patients.
"PREMM5" is a logistic regression model. It calculates the risk of having a mutation in the mismatch repair genes MLH1, MSH2/EPCAM, MSH6 and PMS2 (for single genes and overall) based on the personal and familial cancer history
...
Creators: Christoph Engel, Silke Zachariae, Kastrinos et al.
Contributor: Silke Zachariae
Model type: Not specified
Model format: Not specified
Environment: Not specified
Human Disease: hereditary breast ovarian cancer syndrome
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Abstract (Expand)
Authors: V. Steinke, S. Holzapfel, Markus Löffler, E. Holinski-Feder, M. Morak, H. K. Schackert, H. Gorgens, C. Pox, B. Royer-Pokora, M. von Knebel-Doeberitz, R. Buttner, P. Propping, Christoph Engel
PubMed ID: 24493211
Citation: Int J Cancer. 2014 Jul 1;135(1):69-77. doi: 10.1002/ijc.28650. Epub 2014 Feb 20.