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Depending on the calculated mutation probability genetic counsellors can decide whether patients should undergo further analysis of microsatellite instability and immunohistochemistry. The model is recommended for patients with an age at colorectal cancer diagnosis of 55 or younger.

"MMRpredict" is a risk prediction model for patients with colorectal cancer (Barnetson et al. 2006). It calculates the risk of having a mutation in the mismatch repair genes MLH1, MSH2 and MSH6 (overall probability) based on the familial history of colorectal and endometrium cancers.


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Human Disease: Colorectal cancer

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Created: 13th May 2019 at 14:23

Last updated: 6th Mar 2020 at 09:06

Last used: 24th May 2020 at 18:58

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