The PREMM5 has been developed as a pretest to decide whether patients suspected of having Lynch syndrome should be tested for germline mismatch repair gene mutations. In contrast to "PREMM1,2,6" it can be used to predict mutation probabilities in unaffected index patients.
"PREMM5" is a logistic regression model. It calculates the risk of having a mutation in the mismatch repair genes MLH1, MSH2/EPCAM, MSH6 and PMS2 (for single genes and overall) based on the personal and familial cancer history of the proband (colorectal, endometrial, and other Lynch syndrome related cancers).
Health Atlas ID: 7Q0CEYUJ8R-41 item is associated with this Model:
- https://apps.health-atlas.de/premm5/ (Website)
Organism: Homo sapiens
Human Disease: Hereditary breast ovarian cancer syndrome
Model type: Not specified
Model format: R package
Execution or visualisation environment: Shiny
Model image: No image specified
Created: 13th May 2019 at 14:17
Last updated: 27th Nov 2019 at 12:52
Last used: 28th Feb 2021 at 15:04