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Alfred Winter

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LHA-ID: 7WDQQD33EF-3

Location:  Germany

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Natural Language Processing for Clinical Research

The NLP4CR project was initiated as part of Colleen Goldberg's master thesis. Medical information is not always available in a structured form, but as free text documentation. NLP techniques make it possible to analyse, annotate and extract these free texts. In this way, medical data can be made accessible for machine processing and for clinical research.

Programme: This Project is not associated with a Programme

Public web page: http://www.imise.uni-leipzig.de/Gruppen/MIG

Start date: 1st Jan 2015

Towards Phenotyping of Clinical Trial Eligibility Criteria.
Natural Language Processing for Clinical Research

Abstract (Expand)

BACKGROUND: Medical plaintext documents contain important facts about patients, but they are rarely available for structured queries. The provision of structured information from natural language texts … in addition to the existing structured data can significantly speed up the search for fulfilled inclusion criteria and thus improve the recruitment rate. OBJECTIVES: This work is aimed at supporting clinical trial recruitment with text mining techniques to identify suitable subjects in hospitals. METHOD: Based on the inclusion/exclusion criteria of 5 sample studies and a text corpus consisting of 212 doctor's letters and medical follow-up documentation from a university cancer center, a prototype was developed and technically evaluated using NLP procedures (UIMA) for the extraction of facts from medical free texts. RESULTS: It was found that although the extracted entities are not always correct (precision between 23% and 96%), they provide a decisive indication as to which patient file should be read preferentially. CONCLUSION: The prototype presented here demonstrates the technical feasibility. In order to find available, lucrative phenotypes, an in-depth evaluation is required.

Authors: Matthias Löbe, Sebastian Stäubert, C. Goldberg, I. Haffner, Alfred Winter

Date Published: 5th May 2018

Journal: Stud Health Technol Inform

Human Diseases: breast cancer

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