Supplementary Data for Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding locidagger. Version 1
Health Atlas ID: 7Q0CTG2NR3-0
Data file type: Clinical Data
Human Diseases: No Human Disease specified
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Created: 6th May 2019 at 12:01
Last updated: 4th Jun 2020 at 08:23
Last used: 17th May 2021 at 04:11
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The group is interested in omic-level studies including the genome, methylome, transcriptome, and metabolome of the general population as well as of various diseases including cardiovascular diseases, pneumonia, sepsis, obesity, and brain cancers. Additionally, we aim at transfering results of biomathematical model simulations into clinical practice e.g. by haematopoietic growth-factor opimization during cytotoxic chemotherapy and optimization of EPO applications in chronic kidney disease.
Programme: This Project is not associated with a Programme
Public web page: http://www.imise.uni-leipzig.de/en/Groups/GenStat/
Start date: 1st Jan 2013
Organisms: Homo sapiens
Goal of the Leipzig Research Center for Civilization Diseases (LIFE) is the investigation of civilization diseases like depression, diabetes, allergies or cardiovascular diseases. For this purpose we collect as much data as possible regarding health and living conditions of the population in Leipzig and provide these data for scientists of the University of Leipzig and other research institutions.
The LIFE-Heart study recruited 7,000 patients with suspected coronary heart disease, manifest heart disease or myocardial infarction. All patients received coronary angiography so that the vascular status in the heart is precisely known. In principle, this examination is not feasible in population-related studies. In addition, the patients were thoroughly examined with regard to the general vascular status and the health of the cardiovascular system. Extensive environmental factors were recorded.
Date Published: 15th Aug 2015
Publication Type: Journal article
PubMed ID: 26019233
Citation: Hum Mol Genet. 2015 Aug 15;24(16):4746-63. doi: 10.1093/hmg/ddv194. Epub 2015 May 27.
Projects: LIFE Heart, LIFE - Leipzig Research Center for Civilization Diseases, HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, Genetical Statistics and Systems Biology, COVID-19 Leipzig
Scientific Speaker Institution
Institut für Medizinische Informatik, Statistik und Epidemiologie