peripheral T-cell lymphoma

Details about this human disease

Synonyms (0)

None defined


Definitions (1)

A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus.


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Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial.
GLA - German Lymphoma Alliance

Abstract (Expand)

PTCL patients exhibit poor survival with existing treatments. We investigated the efficacy of CHOP combined with alemtuzumab in 116 PTCL patients age 61-80 in an open-label, randomized phase 3 trial. … Alemtuzumab was given on day 1, to a total of 360 mg in 21 patients, or 120 mg in 37. Hematotoxicity was increased with A-CHOP resulting in more grade >/=3 infections (40% versus 21%) and 4 versus 1 death due to infections, respectively. CR/CRu rate was 60% for A-CHOP and 43% for CHOP, and OR rate was 72% and 66%, respectively. Three-year-EFS, PFS and OS were 27% [15%-39%], 28% [15%-40%], and 37% ([23%-50%] for A-CHOP, and 24% [12%-35%], 29% [17%-41%], and 56% [44%-69%] for CHOP, respectively, showing no significant differences. Multivariate analyses, adjusted for strata and sex confirmed these results (hazard ratio HREFS: 0.7 ([95% CI: 0.5-1.1]; p = 0.094), HRPFS: 0.8 ([95% CI: 0.5-1.2]; p = 0.271), HROS: 1.4 ([95% CI: 0.9-2.4]; p = 0.154). The IPI score was validated, and male sex (HREFS 2.5) and bulky disease (HREFS 2.2) were significant risk factors for EFS, PFS, and OS. Alemtuzumab added to CHOP increased response rates, but did not improve survival due to treatment-related toxicity.

Authors: G. G. Wulf, B. Altmann, M. Ziepert, F. D'Amore, G. Held, R. Greil, O. Tournilhac, T. Relander, A. Viardot, M. Wilhelm, C. Wilhelm, A. Pezzutto, J. M. Zijlstra, E. V. D. Neste, P. J. Lugtenburg, J. K. Doorduijn, M. V. Gelder, G. W. van Imhoff, F. Zettl, F. Braulke, M. Nickelsen, B. Glass, A. Rosenwald, P. Gaulard, M. Loeffler, M. Pfreundschuh, N. Schmitz, L. Trumper

Date Published: 10th May 2020

Publication Type: Journal article

Human Diseases: lymphoma, peripheral T-cell lymphoma

ACT-2 trial data SPSS
GLA - German Lymphoma Alliance
No description specified

Creator: René Hänsel

Submitter: René Hänsel

Data file type: Clinical Data

Human Diseases: peripheral T-cell lymphoma

ACT-2 trial data ODM
GLA - German Lymphoma Alliance
No description specified

Creator: René Hänsel

Submitter: René Hänsel

Data file type: ODM Data

Human Diseases: peripheral T-cell lymphoma

ACT-2 trail data CSV
GLA - German Lymphoma Alliance
No description specified

Creator: René Hänsel

Submitter: René Hänsel

Data file type: Clinical Data

Human Diseases: peripheral T-cell lymphoma

ACT-2 trial data odm-Metadata
GLA - German Lymphoma Alliance
No description specified

Creator: René Hänsel

Submitter: René Hänsel

Data file type: ODM Data

Human Diseases: peripheral T-cell lymphoma

Download
ACT-2 trial data Metadata
GLA - German Lymphoma Alliance
No description specified

Creator: René Hänsel

Submitter: René Hänsel

Data file type: Clinical Data

Human Diseases: peripheral T-cell lymphoma

Download

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