Data files
The dataset contains data from 3,786 patients. It is not available for download here, but registered in the FAIR4Health Platform portal.
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This file contains the FHIR CapabilityStatement and FHIR Provenance ressources created within this use case in the local onFHIR store. It covers both #1 Characterization of multimorbidity patterns and association with health outcomes in the elderly and #2 Early prediction service for 30-days readmission risk in COPD patients.
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SCALE-TORT database contains a total of 226 FP/IR paired arterial vessel curves and 245 FP/IR paired vein vessel curves, all 471 paried curves where semiautomatically extracted from the original images.
- Folder 'im_arteries' with: 1.1 226 croped images from FP of retinal arteries 1.2 226 croped images from IR of retinal arteries
- Folder 'im_veins' with: 2.1. 245 croped images from FP of retinal veins 2.2. 245 croped images from IR of retinal veins
- Matlab structure for arteries annotations ...
Creators: None
Submitter: Zian Fanti Gutiérrez
Data file type: Clinical Data
Human Diseases: hypertension
For our R-based workflow on GitHub pulmonologists_interspecies_scRNA, we here provide the processed resulting annotated integrated Seurat file.
References for original datasets :
Human Charité: Hocke A, Hönzke K, Obermayer B, Baumgardt M, Wyler E, Hippenstiel S, Mache C. Charité Berlin /Berlin Institute of Health. GEO accessions GSM5958267, GSM5958272, GSM5958283, GSM5958285
Human Travaglini et al.: published at ...
Group Overexpression Spot J from Cheng oposSOM. Most of the samples in this spot are SG cells
Group Overexpression Spot K from Joost oposSOM. Most of the samples in this spot are SG cells
307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS wild type, BRAF mutant/NRAS wild type and BRAF wild type/NRAS mutant melanoma metastasis, respectively
Creators: Hans Binder, Henry Löffler-Wirth, Manfred Kunz
Submitter: Christoph Beger
Data file type: Genomic Data
Human Diseases: melanoma
OBJECTIVES: Although patients with depression often suffer from sleep disturbances, most of them are not sleepy. Upregulation of brain arousal has been proposed as pathophysiological mechanism explaining sleep disturbances, inner tension, autonomic hyperarousal and anhedonia in depression. The aim of the current study was to examine the association between night-time sleep disturbances and brain arousal regulation the next day in depressed versus non-depressed subjects. METHODS: Twenty-eight ...
We performed gene-expression analysis of 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A SOM was trained using molecular classification of specimen according to molecular Burkitt's Lymphoma score provided by Hummel et al.
Creator: Henry Löffler-Wirth
Submitters: Henry Löffler-Wirth, Christoph Beger
Data file type: SOM Data
We present a transcriptome map of mature B-cell lymphomas that was obtained by analyzing expression data of 873 biopsy specimens including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt’s lymphoma (BL), mixed FL/DLBCL lymphomas, primary mediastinal large B-cell lymphoma (PMBL), multiple myeloma (MM), IRF4-rearranged large cell lymphoma, MYC-negative high-grade B-cell lymphomas with Chr. 11q aberration pattern (mnBLL-11q), and Mantle cell lymphoma (MCL) to describe their ...
Creator: Henry Löffler-Wirth
Submitters: Henry Löffler-Wirth, Christoph Beger
Data file type: SOM Data
For this study, we screened prospectively recruited patients with a histopathological reference diagnosis of cerebral tumors of WHO grade II and III, known KPS at diagnosis, information on extent of resection by early postoperative neuroimaging, available frozen tissue specimens from the initial operation, and documented clinical outcome.
Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological ...
Single-cell transcriptomics has been used for analysis of heterogeneous populations of cells during developmental processes and for analysis of tumor cell heterogeneity. More recently, analysis of pseudotime (PT) dynamics of heterogeneous cell populations has been established as a powerful concept to study developmental processes. Here we perform PT analysis of 3 melanoma short-term cultures with different genetic backgrounds to study specific and concordant properties of PT dynamics of selected ...
Recent technological advances in single-cell genomics make it possible to analyze cellular heterogeneity of tumor samples. Here, we applied single-cell RNA-seq to measure the transcriptomes of 307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS wild type, BRAF mutant/NRAS wild type and BRAF wild type/NRAS mutant melanoma metastasis, respectively. Analysis based on self-organizing maps identified sub-populations defined by multiple gene expression modules ...
Colorectal cancer (CRC) arising in Lynch syndrome (LS) comprises tumours with constitutional mutations in DNA mismatch repair genes. There is still a lack of whole-genome and transcriptome studies of LS-CRC to address questions about similarities and differences in mutation and gene expression characteristics between LS-CRC and sporadic CRC, about the molecular heterogeneity of LS-CRC, and about specific mechanisms of LS-CRC genesis linked to dysfunctional mismatch repair in LS colonic mucosa and ...
Creator: Hans Binder
Submitter: Henry Löffler-Wirth
Data file type: SOM Data
Human Diseases: Lynch syndrome
Creator: Maciej Rosolowski
Submitter: Maciej Rosolowski
Data file type: SOM Data
Human Diseases: head and neck squamous cell carcinoma
We present an extensive and detailed study on the gene expression landscape of peripheral blood of healthy individuals based on transcriptome data of 3,388 individuals screened in the population study LIFE between 2011 and 2014. For analysis we applied a neural network technique using self-organizing maps (SOM). Our home-made R-program ‘oposSOM’ enables to reduce the dimension of expression data from tens of thousands of genes to a few thousand ‘meta-genes’ and generates portraits of transcriptional ...
Creator: Henry Löffler-Wirth
Submitters: Henry Löffler-Wirth, Christoph Beger
Data file type: SOM Data
The lipid-secreting sebaceous glands (SG) are indispensable for maintaining skin structure and function, and may influence whole body’s energy metabolism. SG deregulation is also associated with a number of skin disorders, including but not limited to acne. Here, we exploit the high cellular resolution provided by sebaceous hyperplasia to spatially characterize the human SG transcriptional program. By integrating single-cell spatial transcriptomics, pseudotime analysis, RNA velocity, and functional ...
Creators: Maria Schmidt, Henry Löffler-Wirth, Hans Binder, Marlon Schneider
Submitter: Henry Löffler-Wirth
Data file type: Transcriptomic Data
Summary statistics from meta GWAS of 17-OH-progesterone for
- all samples (adjusted for age, log(BMI) and sex)
- men only (adjusted for age and log(BMI))
- women only (adjusted for age and log(BMI))
These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge the source ...
Summary statistics from meta GWAS of aldosterone for
- all samples (adjusted for age, log(BMI) and sex)
- men only (adjusted for age and log(BMI))
- women only (adjusted for age and log(BMI))
These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge the source as ...
Summary statistics from meta GWAS of androstenedione for
- all samples (adjusted for age, log(BMI) and sex)
- men only (adjusted for age and log(BMI))
- women only (adjusted for age and log(BMI))
These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge the source ...
Summary statistics from GWAMA of brassicasterol (bre, esterified brassicasterol; brf, free brassicasterol; brt, total brassicasterol; brf_bre, free to esterified brassicasterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using this data acknowledge the source as follows: 'Data on ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from GWAMA of brassicasterol (brf_chf, free brassicasterol to free cholesterol; brt_cht, total brassicasterol to total cholesterol; brf_laf, free brassicasterol to free lanosterol; brt_laf, total brassicasterol to free lanosterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from GWAMA of campesterol (cae, esterified campesterol; caf, free campesterol; cat, total campesterol; caf_cae, free to esterified campesterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using this data acknowledge the source as follows: 'Data on campesterol has been ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from GWAMA of campesterol (caf_chf, free campesterol to free cholesterol; cat_cht, total campesterol to total cholesterol; caf_laf, free campesterol to free lanosterol; cat_laf, total campesterol to free lanosterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from meta GWAS of cortisol for
- all samples (adjusted for age, log(BMI) and sex)
- men only (adjusted for age and log(BMI))
- women only (adjusted for age and log(BMI))
These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge the source as ...
Summary statistics from GWAS of CPA_max for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on area of the largest plaque detected has been contributed by LIFE-Adult investigators and has been ...
Summary statistics from GWAS of CPA_mean for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on mean area of detected plaques has been contributed by LIFE-Adult investigators and has been downloaded ...
Summary statistics from GWAS of CPA_sum for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on sum of plaque areas has been contributed by LIFE-Adult investigators and has been downloaded from ...
Summary statistics from GWAS of CPS_max for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on maximal degree of stenosis has been contributed by LIFE-Adult investigators and has been downloaded ...
Summary statistics from GWAS of CPS_mean for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on mean degree of stenosis has been contributed by LIFE-Adult investigators and has been downloaded ...
Summary statistics from GWAS of CPS_sum for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on sum of stenosis has been contributed by LIFE-Adult investigators and has been downloaded from ...
Summary statistics from meta GWAS of DHEAS for
- all samples (adjusted for age, log(BMI) and sex)
- men only (adjusted for age and log(BMI))
- women only (adjusted for age and log(BMI))
These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge the source as follows: ...
Summary statistics from meta GWAS of estradiol for
- all samples (adjusted for age, log(BMI) and sex)
- men only (adjusted for age and log(BMI))
- women only (adjusted for age and log(BMI))
These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge the source as ...
Summary statistics from GWAMA of PCSK9 levels. These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using this data acknowledge the source as follows: 'Data on PCSK9 has been downloaded from https://www.health-atlas.de/data_files/551'
We make three data sets available:
- Containing statistics ...
Creator: Janne Pott
Submitter: Janne Pott
Data file type: Not specified
Human Diseases: atherosclerosis
Summary statistics from meta GWAS of progesterone for
- all samples (adjusted for age, log(BMI) and sex)
- men only (adjusted for age and log(BMI))
- women only (adjusted for age and log(BMI))
These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge the source as ...
Summary statistics from GWAMA of sitosterol (sie, esterified sitosterol; sif, free sitosterol; sit, total sitosterol; sif_sie, free to esterified sitosterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using this data acknowledge the source as follows: 'Data on sitosterol has been ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from GWAMA of sitosterol (sif_chf, free sitosterol to free cholesterol; sit_cht, total sitosterol to total cholesterol; sif_laf, free sitosterol to free lanosterol; sit_laf, total sitosterol to free lanosterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using this ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from GWAMA of stigmasterol (ste, esterified stigmasterol; stf, free stigmasterol; stt, total stigmasterol; stf_ste, free to esterified stigmasterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using this data acknowledge the source as follows: 'Data on stigmasterol ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from GWAMA of stigmasterol (stf_chf, free stigmasterol to free cholesterol; stt_cht, total stigmasterol to total cholesterol; stf_laf, free stigmasterol to free lanosterol; stt_laf, total stigmasterol to free lanosterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from meta GWAS of testosterone for
- all samples (adjusted for age, log(BMI) and sex)
- men only (adjusted for age and log(BMI))
- women only (adjusted for age and log(BMI))
These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge the source as ...
Extended table 1 including Ensembl identifier for transcripts jointly upregulated in human and mouse sebaceous gland cells.
Extended table 3 including Ensembl identifier of peroxisomal transcripts (GO:0005777) upregulated in human and mouse sebaceous gland cells.
PURPOSE: The aim of this study was to test psychometric properties of the Satisfaction with Life Scale (SWLS), to provide normative values, and to analyze associations between life satisfaction and sociodemographic and behavioral data. METHODS: A German community sample (n = 9711) with an age range of 18-80 years was surveyed using the SWLS and several other questionnaires. Confirmatory factor analysis (CFA) was used to test the dimensionality of the SWLS. Invariance across gender and age groups ...
