The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany.

Abstract:

BACKGROUND: The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in the east of Germany. It is the first study of this kind and size in an urban population in the eastern part of Germany. The study is conducted by the Leipzig Research Centre for Civilization Diseases (LIFE). Our objective is to investigate prevalences, early onset markers, genetic predispositions, and the role of lifestyle factors of major civilization diseases, with primary focus on metabolic and vascular diseases, heart function, cognitive impairment, brain function, depression, sleep disorders and vigilance dysregulation, retinal and optic nerve degeneration, and allergies. METHODS/DESIGN: The study covers a main age range from 40-79 years with particular deep phenotyping in elderly participants above the age of 60. The baseline examination was conducted from August 2011 to November 2014. All participants underwent an extensive core assessment programme (5-6 h) including structured interviews, questionnaires, physical examinations, and biospecimen collection. Participants over 60 underwent two additional assessment programmes (3-4 h each) on two separate visits including deeper cognitive testing, brain magnetic resonance imaging, diagnostic interviews for depression, and electroencephalography. DISCUSSION: The participation rate was 33 %. The assessment programme was accepted well and completely passed by almost all participants. Biomarker analyses have already been performed in all participants. Genotype, transcriptome and metabolome analyses have been conducted in subgroups. The first follow-up examination will commence in 2016.

LHA-ID: 7Q6RC6AHEY-6

PubMed ID: 26197779

Projects: LIFE Adult

Journal: BMC Public Health

Human Diseases: Cognitive disorder, Mental depression, Disease of metabolism, Vascular disease, Allergic hypersensitivity disease, Sleep disorder, Retinal degeneration

Citation: BMC Public Health. 2015 Jul 22;15:691. doi: 10.1186/s12889-015-1983-z.

Date Published: 22nd Jul 2015

Authors: Markus Löffler, Christoph Engel, P. Ahnert, D. Alfermann, K. Arelin, R. Baber, F. Beutner, Hans Binder, E. Brahler, R. Burkhardt, U. Ceglarek, C. Enzenbach, M. Fuchs, H. Glaesmer, F. Girlich, A. Hagendorff, M. Hantzsch, U. Hegerl, S. Henger, T. Hensch, Andreas Hinz, V. Holzendorf, D. Husser, A. Kersting, A. Kiel, Toralf Kirsten, J. Kratzsch, K. Krohn, Tobias Luck, S. Melzer, J. Netto, M. Nuchter, M. Raschpichler, F. G. Rauscher, Steffi Gerlinde Riedel-Heller, Christian Sander, Markus Scholz, P. Schonknecht, M. L. Schroeter, J. C. Simon, R. Speer, J. Staker, R. Stein, Y. Stobel-Richter, M. Stumvoll, A. Tarnok, A. Teren, D. Teupser, F. S. Then, A. Tonjes, R. Treudler, A. Villringer, A. Weissgerber, P. Wiedemann, Silke Zachariae, K. Wirkner, J. Thiery

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