Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)

Study Group
Kompetenznetzes Sepsis (SepNet)

In critical illness, a significant reduction in mortality was recently achieved by strict glycemic control, however it has to be determined whether this is true and safe for patients with sepsis as well.

Severe sepsis and septic shock have a high mortality. Research has concentrated on adjunctive sepsis therapies; the role of supportive measures is comparatively unclear. In Europe the use of colloids is widespread, but there is no evidence on the role of either crystalloid or colloid volume therapy in sepsis. Recently, a higher incidence of kidney failure in sepsis was reported after administration of colloids.
Founding Year
German Federal Ministry of Education and Research (BMBF) FKZ 01 KI 0106
B. Braun
Novo Nordisk
German Competence Network Sepsis
Scientific Speaker
Prof. Dr. Konrad Reinhart
Scientific Speaker Institution

Department of Anesthesiology and
Intensive Care Medicine
Friedrich Schiller University of Jena
Erlanger Allee 101
07747 Jena

Scientific Speaker eMail
Registration Number
Human Disease Ontology Concept