Version 1

Motivation: The eClaus model can be used to calculate mutation risks for BRCA1/2 as well as life-time risks for breast cancer in women from families with multiple and/or early onset cases of breast and ovarian cancer. The model can be used to assist genetic counselors in clinical decision making regarding genetic testing, intensified surveillance, and prophylatic surgery.

Description: The Claus model is a genetic breast cancer risk calculation model assuming a single rare, highly penetrant gene. The extended version of the Claus model (eClaus), as implemented in the commercial pedigree drawing software CYRILLIC 2.1.3, calculates BRCA1/2 mutation probabilities and breast cancer risks for female individuals (test persons) based on their personal and familial cancer histories.


1 item is associated with this Model:

Human Disease: Hereditary breast ovarian cancer syndrome

Model type: Not specified

Model format: R package

Execution or visualisation environment: Shiny

Model image: No image specified

help Creators and Submitter
Additional credit

Claus, E.B. et al. (1991 and 1994)


Views: 4704

Created: 1st Apr 2019 at 11:01

Last updated: 27th Nov 2019 at 12:53

Last used: 20th May 2024 at 13:11

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Version History

Version 1 Created 1st Apr 2019 at 11:01 by Silke Zachariae

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