The eClaus model can be used to calculate mutation risks for BRCA1/2 as well as life-time risks for breast cancer in women from families with multiple and/or early onset cases of breast and ovarian cancer. The model can be used to assist genetic counselors in clinical decision making regarding genetic testing, intensified surveillance, and prophylatic surgery.
The Claus model is a genetic breast cancer risk calculation model assuming a single rare, highly penetrant gene. The extended version of the Claus model (eClaus), as implemented in the commercial pedigree drawing software CYRILLIC 2.1.3, calculates BRCA1/2 mutation probabilities and breast cancer risks for female individuals (test persons) based on their personal and familial cancer histories.
Health Atlas ID: 7Q0CEYUHXW-11 item is associated with this Model:
- https://apps.health-atlas.de/pedin/ (Website)
Organism: Homo sapiens
Human Disease: Hereditary breast ovarian cancer syndrome
Model type: Not specified
Model format: R package
Execution or visualisation environment: Shiny
Model image: No image specified
Created: 1st Apr 2019 at 11:01
Last updated: 27th Nov 2019 at 12:53
Last used: 27th Jan 2021 at 17:21