Based on the assumption that molecular mechanisms involved in cancerogenesis are characterized by groups of coordinately expressed genes, we developed and validated a novel method for analyzing transcriptional data called Correlated Gene Set Analysis (CGSA). Using 50 extracted gene sets we identified three different profiles of tumors in a cohort of 364 Diffuse large B-cell (DLBCL) and related mature aggressive B-cell lymphomas other than Burkitt lymphoma.
We analyzed a cohort consisting of 364 DLBCL and related mature aggressive B-cell lymphomas other than Burkitt lymphoma. All cases of this cohort were collected within the network project Molecular Mechanisms in Malignant Lymphoma (MMML).
Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Universität Leipzig Härtelstraße 16-18 04107 LEIPZIG