Publications

958 Publications visible to you, out of a total of 958

Abstract

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Authors: Elske Ammenwerth, Petra Knaup-Gregori, Alfred Winter, A.W. Bauer, O.J. Bott, M. Gietzelt, B. Haarbrandt, W.O. Hackl, N. Hellrung, G. Hübner-Bloder, Franziska Jahn, M.W. Jaspers, U. Kutscha, C. Machan, B. Oppermann, J. Pilz, J. Schwartze, C. Seidel, J.E. Slot, S. Smers, K. Spitalewski, N. Steckel, Alexander Strübing, M. van der Haak, Reinhold Haux, W.J. ter Burg

Date Published: 31st Jan 2018

Publication Type: Journal article

Abstract

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Authors: Sebastian Stäubert, Michael Schaaf, Franziska Jahn, Ralf Brandner, Alfred Winter

Date Published: 22nd Jan 2018

Publication Type: Journal article

Abstract (Expand)

The publication of a memorandum on improving medication safety by information technology in both the German journal GMS Medical Informatics, Biometry and Epidemiology (MIBE) and the journal Methods of Information in Medicine (MIM) gives reason to strengthen cooperation of MIBE and MIM and to report on more publications of MIBE here. The publications in focus deal with simulation-based optimization of emergency processes, handling of research data in publications, open access to research metadata, reliability of digital patient records in medical research, assessment methods for physical activity, using of insurance databases for epidemiological studies, certificates for epidemiological professionals, regression models, computer based training, and performance management in Swiss hospitals. Finally determining factors for scientific careers are discussed.

Authors: Alfred Winter, R. D. Hilgers, R. Hofestadt, Petra Knaup-Gregori, C. Ose, A. Timmer

Date Published: 20th Jan 2018

Publication Type: Journal article

Abstract

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Authors: T. Nitzsche, S. Thiele, A. Häber, Alfred Winter

Date Published: 20th Jan 2018

Publication Type: Journal article

Abstract (Expand)

Intestinal stem cells (ISCs) require well-defined signals from their environment in order to carry out their specific functions. Most of these signals are provided by neighboring cells that form a stem cell niche, whose shape and cellular composition self-organize. Major features of this self-organization can be studied in ISC-derived organoid culture. In this system, manipulation of essential pathways of stem cell maintenance and differentiation results in well-described growth phenotypes. We here provide an individual cell-based model of intestinal organoids that enables a mechanistic explanation of the observed growth phenotypes. In simulation studies of the 3D structure of expanding organoids, we investigate interdependences between Wnt- and Notch-signaling which control the shape of the stem cell niche and, thus, the growth pattern of the organoids. Similar to in vitro experiments, changes of pathway activities alter the cellular composition of the organoids and, thereby, affect their shape. Exogenous Wnt enforces transitions from branched into a cyst-like growth pattern; known to occur spontaneously during long term organoid expansion. Based on our simulation results, we predict that the cyst-like pattern is associated with biomechanical changes of the cells which assign them a growth advantage. The results suggest ongoing stem cell adaptation to in vitro conditions during long term expansion by stabilizing Wnt-activity. Our study exemplifies the potential of individual cell-based modeling in unraveling links between molecular stem cell regulation and 3D growth of tissues. This kind of modeling combines experimental results in the fields of stem cell biology and cell biomechanics constituting a prerequisite for a better understanding of tissue regeneration as well as developmental processes.

Authors: T. Thalheim, M. Quaas, M. Herberg, U. D. Braumann, C. Kerner, M. Loeffler, G. Aust, J. Galle

Date Published: 15th Jan 2018

Publication Type: Not specified

Human Diseases: colonic disease

Abstract

Not specified

Authors: Alfred Winter, R.-D. Hilgers, R. Hofestädt, Petra Knaup-Gregori, C. Ose, A. Timmer

Date Published: 8th Jan 2018

Publication Type: Journal article

Abstract

Not specified

Authors: Christian R. Bauer, T. Ganslandt, B. Baum, J. Christoph, I. Engel, Matthias Löbe, S. Mate, Sebastian Stäubert, J. Drepper, Hans-Ulrich Prokosch, Alfred Winter, U. Sax

Date Published: 8th Jan 2018

Publication Type: Journal article

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