Publications

960 Publications visible to you, out of a total of 960

Abstract

Not specified

Authors: Matthias Löbe, O. Beyan, Sebastian Stäubert, Frank A. Meineke, D. Ammon, Alfred Winter, S. Deckert, Markus Löffler, Toralf Kirsten

Date Published: 2019

Publication Type: InProceedings

Abstract (Expand)

Many healthcare IT systems in Germany are unable to interoperate with other systems through standardised data formats. Therefore it is difficult to store and retrieve data and to establish a systematic collection of data with provenance across systems and even healthcare institutions. We outline the concept for a Transformation Pipeline that can act as a processor for proprietary medical data formats from multiple sources. Through a modular construction, the pipeline relies on different data extraction and data enrichment modules as well as on interfaces to external definitions for interoperability standards. The developed solution is extendable and reusable, enabling data transformation independent from current format definitions and entailing the opportunity of collaboration with other research groups.

Authors: Lo An Phan-Vogtmann, A. Helborn, Henner M. Kruse, E. Thomas, Andrew J. Heidel, K. Saleh, F. Rissner, M. Specht, A. Henkel, A. Scherag, D. Ammon

Date Published: 2019

Publication Type: Journal article

Abstract

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Authors: B. Schreiweis, D. Ammon, M. Sedlmayr, F. Albashiti, T. Wendt

Date Published: 2019

Publication Type: InBook

Abstract

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Authors: S. Zabka, D. Ammon, T. Ganslandt, J. E. Gewehr, C. Haverkamp, S. Kiefer, H. Lautenbacher, Matthias Löbe, S. Thun, M. Boeker

Date Published: 2019

Publication Type: InProceedings

Abstract (Expand)

BACKGROUND A significant proportion of patients develop left ventricular (LV) remodeling leading to heart failure after acute myocardial infarction (AMI). Being able to identify these patients wouldd represent a step forward towards personalized medicine. The present study aimed to determine the ability of cyclin dependent kinase inhibitor 1C (CDKN1C) to risk stratify AMI patients, in a sex-specific manner. METHODS CDKN1C expression was measured in blood samples obtained at admission in a test cohort of 447 AMI patients and a validation cohort of 294 patients. The study end-point was LV function assessed by the ejection fraction (EF) at follow-up. RESULTS In the test cohort, CDKN1C was lower in patients with a reduced EF (\textless40%) compared to patients with preserved EF (\geq50%). This observation was specific to women. CDKN1C was a significant univariate predictor of LV function in women only. In multivariable analysis including demographic and clinical parameters, CDKN1C predicted LV function in women (odds ratio [95% confidence interval] 0.44 [0.23-0.82]) but not in men (0.90 [0.70-1.16]). Addition of CDKN1C to a multivariable clinical model reduced the Akaike information criterion, attesting for an incremental predictive value, in women (p = 0.006) but not in men (p = 0.41). Bootstrap internal validation confirmed the added value of CDKN1C in women. The female-specific predictive value of CDKN1C was validated in the independent cohort. CONCLUSION CDKN1C is a novel female-specific biomarker of LV function after AMI.

Authors: Torkia Lalem, Lu Zhang, Markus Scholz, Ralph Burkhardt, Victoria Saccheti, Andrej Teren, Joachim Thiery, Yvan Devaux

Date Published: 2019

Publication Type: Journal article

Abstract

Not specified

Authors: Paul Schmücker, Ulrike Schemman, Alfred Winter, Oliver Bott, Petra Knaup-Gregori, Stefan Kropf, Heinrich Lautenbacher, An Lo Phan-Vogtmann, André Scherag, Cord Spreckelsen

Date Published: 2019

Publication Type: Journal article

Abstract

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Authors: Sebastian Stäubert, Alexander Strübing, J. Drepper, B. Bergh, Alfred Winter, A. Merzweiler

Date Published: 2019

Publication Type: InCollection

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