Relationship between fermented dairy consumption, circulating short-chain acylcarnitines and angiographic severity of coronary artery disease

Abstract:

BACKGROUND AND AIMS Current epidemiologic data suggest beneficial cardiovascular effects of fermented dairy products (FDP). However, the relationship between FDP consumption and angiographic coronary status has not been previously studied. Furthermore, the role of novel metabolomic biomarkers of cardiovascular risk in this context is unclear. We hypothesize that short-chain acylcarnitines (SCA) reflect the link between FDP intake and angiographic extent of stable coronary artery disease (CAD). METHODS AND RESULTS We recruited 1185 patients admitted for suspected CAD [median age 62 years (interquartile range: 54-69); 714 men (60.3%)]. Prior to coronary angiography, each patient completed a validated Food Frequency Questionnaire. In addition, venous blood was collected from each patient for whole blood metabolomic analysis, using targeted mass-spectrometry. CAD was defined by the presence of \geq1 coronary stenosis \geq50%. Patients with CAD (n = 441) reported lower median FDP intake [86.8 g/day (IQR: 53.4-127.6)] than patients without CAD [n = 744; 103.9 g/day (IQR: 62.9-152.7); p \textless 0.001]. Upon adjustment for relevant confounders, increased circulating SCA, particularly level of acetylcarnitine (C2) associated with both higher CAD probability [SCA:\textgreekb(SE) = 0.584 (0.235), p = 0.013; C2:\textgreekb(SE) = 0.575 (0.242), p = 0.017] and decreased FDP consumption [SCA:\textgreekb/100 g FDP-increment/day (SE) = -0.785 (0.242), p = 0.001; C2:\textgreekb(SE) = -0.560 (0.230), p = 0.015]. By mediation analysis, neither SCA nor C2 showed relevant mediator effect linking FDP consumption to the risk of CAD. CONCLUSION Increased consumption of fermented milk was associated with lower prevalence of CAD and correlated inversely with circulating SCA, in particular with acetylcarnitine. No substantial mediator effect of SCA linking fermented milk intake with risk of CAD was found. CLINICAL TRIAL REGISTRY NCT00497887.

PubMed ID: 32684363

DOI: 10.1016/j.numecd.2020.05.031

Projects: Genetical Statistics and Systems Biology

Publication type: Journal article

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD

Human Diseases: No Human Disease specified

Citation: Nutrition, Metabolism and Cardiovascular Diseases 30(10):1662-1672

Date Published: 1st Sep 2020

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Registered Mode: imported from a bibtex file

Authors: Andrej Teren, Anika Vogel, Frank Beutner, Stephan Gielen, Ralph Burkhardt, Markus Scholz, Joachim Thiery, Uta Ceglarek

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Teren, A., Vogel, A., Beutner, F., Gielen, S., Burkhardt, R., Scholz, M., Thiery, J., & Ceglarek, U. (2020). Relationship between fermented dairy consumption, circulating short-chain acylcarnitines and angiographic severity of coronary artery disease. In Nutrition, Metabolism and Cardiovascular Diseases (Vol. 30, Issue 10, pp. 1662–1672). Elsevier BV. https://doi.org/10.1016/j.numecd.2020.05.031
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Created: 15th Sep 2020 at 08:49

Last updated: 7th Dec 2021 at 17:58

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