Models

The platform is intended for visualization of expression- and mutation-driven changes in biological pathway activities in cancer datasets available in ICGC. The impact of somatic mutations on protein-protein interactions were calculated using Mechismo. Overall activity of biological pathway was evaluated using Pathway Signal Flow algorithm. The application provides interactive heatmaps for pathway output sink node activities and pathway images with mapped affected interactions and output node ...

The interim results are the results from the local statistical analysis at each centre, which were subsequently pooled in the mixed effects meta-analysis.

Note, that the centres are pseudonymised. Interim results are provided for the subset of centres (out of ten), who provided their consent for sharing the results as they were used for the meta-analysis. The pseudonymised names are those that are mentioned in some of the text files for the meta-analysis.

The folder suffix identifies whether ...