Projects

This population-based study examined 10,000 participants randomly selected from the Leipzig population (2011 to 2014). A follow-up is to be carried out from 2017 - 2020. The study mainly included people aged between 40 and 79. All participants underwent a 6-hour study program and people over 60 years of age were invited two more times to in-depth study of cognition and depression and the brain (MRI, EEG). Extensive measurements of genome, metabolome and transcriptome are available. The LIFE-ADULT ...

The aim of oBIG is to establish modern genome bioinformatics in Armenia to investigate genesis and progression of complex diseases. Therefore we will extend the collaboration between the Interdisciplinary Center for Bioinformatics (IZBI) of Leipzig University and the Institute of Molecular Biology (IMB) in Yerevan, Armenia, to accomplish three main aspects of the project:Firstly, current research topics in systems biology of cancer, lung diseases and infections will be addressed by a joint team ...

The vision of Immune Safety Avatar (imSAVAR) is to develop a platform for integrated nonclinical assessments of immunomodulatory therapy safety and efficacy.The imSAVAR is an Innovative Medicines Initiative funded project that aims to develop a standard for integrated nonclinical safety overviews for immune-modulatory investigational new drugs (IND) and clinical trial applications (CTA).Our imSAVAR platform will improve the prediction of the transferability of safety and efficacy of immunomodulators ...

MMML-MYC-SYS is a interdisciplinary consortium where partners from clinical haemaoncological study groups, pathologists, geneticicts, cell biologists as well as mathematicians, statisticians and bioinformaticists have allied. The goal is to investigate the process of development of B-cell lymphoma under special consideration of mutation of MYC. MYC is known to support the development and growth of tumors. This consortium collected and evaluated comprehensive molecular-genetic data for this purpose. ...

The Leipzig Melanoma Studies project consists of studies of the Department of Dermatology, Venereology and Allergology (Leipzig University), Interdisciplinary Center for Bioinformatics (IZBI, Leipzig University) and the Max Planck Institute for Evolutionary Anthropology Leipzig. Single cell transcriptome analyses of melanoma cases and cultures where preformed in the studies.