Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humans
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Created: 26th Apr 2023 at 15:43
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Background Single-cell RNA sequencing (scRNAseq) has been widely applied to dissect cellular heterogeneity in normal and diseased skin. Sebaceous glands, essential skin components with established functions in maintaining skin integrity and emerging roles in systemic energy metabolism, have been largely neglected in scRNAseq studies. Methods Departing from mouse and human skin scRNAseq datasets, we identified gene sets expressed especially in sebaceous glands with the open-source R-package oposSOM. ...
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Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep. 2018 Oct 23;25(4):871-883. doi: 10.1016/j.celrep.2018.09.006. PMID: 30355494; PMCID: PMC6367716.
European Genome-Phenome Archive ...
Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep. 2018 Oct 23;25(4):871-883. doi: 10.1016/j.celrep.2018.09.006. PMID: 30355494; PMCID: PMC6367716.
European Genome-Phenome Archive ...
Group Overexpression Spot J from Cheng oposSOM. Most of the samples in this spot are SG cells
Group Overexpression Spot K from Joost oposSOM. Most of the samples in this spot are SG cells
Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lönnerberg P, Linnarsson S, Kasper M. Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity. Cell Syst. 2016 Sep 28;3(3):221-237.e9. doi: 10.1016/j.cels.2016.08.010. Epub 2016 Sep 15. PMID: 27641957; PMCID: PMC5052454
GEO the accession number: GSE67602
https://orcid.org/0000-0001-5489-7405
Projects: funny dummy, Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humans
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