Pathway signal flow (PSF) algorithm calculates activity of cellular signalling cascades for selected pathways (KEGG database).
Reports show an overview about the pathways along with genes contained in data (p.1 in PDF) and sink nodes (p.2).
Additionally, the signal strength is visualized for each histological subtype (p.3 ff).
Transcriptome Analytics Browser - Tour (part 4 of 5)
Task III: Functional mining
We applied Pathway Signal Flow (PSF) algorithm to calculate activity of cellular signalling. Importantly, this approach explicitly involves pathway topologies and provides proper visualization of the signal strengths.
Several pathways can be inspected using the select box.