Studies

A meta-analysis of genome-wide associations for serum vaspin from six independent cohorts (N = 7446) was conducted. The data show that serum vaspin is strongly determined by genetic variants within vaspin.

This study belongs to the publication: https://doi.org/10.1002/oby.23882

The test data

• are freely invented by clinical experts (manually, synthetically) and have no relation to real persons
• have been generated by a tool developed at the University of Leipzig from contributions of different expert groups out of a MS Excel format
• are available for free use as HL7® FHIR® bundles in json format;
• are suitable for direct transfer into a FHIR server
• correspond as far as ...

A collection of Bulletins of the Institute for Medical Informatics, Statistics and Epidemiology (IMISE) about the COVID-19 pandemic in Leipzig and Saxony. This work was funded in the framework of the project SaxoCOV (Saxonian COVID-19 Research Consortium, SaxoCOV was financed by the Free State of Saxony).”

To achieve the objective of Use Case 1, a retrospective study has been performed with data from 5 EU cohorts in different health care settings (hospital, primary care, nursing homes) and health research organizations:

1. UNIGE: provides anonymized health care data from the EHR of the University Hospitals of Geneva.
2. SAS: provides health care data from the EHR of the Virgen del Rocío University Hospital in Seville as part of the Andalusian Health Service.
3. UCSC: provides health ...

In this study we used the Core Ontology of Phenotypes as general phenotypic model to represent phenotype knowledge. The phenotypes are modelled in so called Phenotype Specification Ontologies.

Summary statistics of Meta-GWAS results will be made available upon acceptance of our manuscript.

In our manuscript, we describe current procedures, tools, and results to create, compare and qualitatively assess the single-cell transcriptomes of the lung in three different species; human (Homo sapiens), hamster (Mesocricetus auratus), and mice (Mus musculus). We make the analysis reproducible by publishing the R-based workflow on GitHub pulmonologists_interspecies_scRNA. Here in the LHA, we provide the required scRNA-Seq ...

Genome-wide Association Meta-Analyses of four steroid hormones (progesterone, 17-OH-progesterone, androstenedione, and aldosterone) and the ratio of testosterone to estradiol. Summary statistics of GWAMA results will be made available upon acceptance of our manuscript.

Genome-wide Association Meta-Analyses of 32 phytosterol traits reflecting resorption, cholesterol synthesis and esterification in six studies with up to 9,758 subjects Summary statistics of GWAMA results will be made available upon acceptance of our manuscript.

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

We analysed if measuring PWV in different segments of the body leads to association with different genetic variants, as well as different heritability and different genetic correlation with other biological traits. Furthermore we searched for shared genetic architecture concerning PWV, blood pressure (BP) and coronary artery disease (CAD) and examined the causal relationship between PWV and BP.

We evaluated if the PhenoMan returns correct/complete result sets and if it is working with real data. To simulate a FHIR health data store with real data we used Synthea(TM) to generate a large data set and imported it into a HAPI FHIR JPA Server. Based on the synthetic data set we developed ten example queries with different structure and complexity with PhenoMan and SQL. We compared the results of the queries in means of execution time and equality of results.

The detailed steps of the evaluation ...

We defined six operationalizations of CPB considering plaques in common carotid arteries, carotid bulb, and internal carotid arteries (maximal plaque area, mean plaque area, sum of plaque areas at all six regions, maximal degree of stenosis, mean degree of stenosis, and sum of stenosis at all six regions). Link to publication (PMID, DOI), Supplemental Figures and Tables, and Summary Statistics of GWAS will be made available upon acceptance of our manuscript.

Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)

Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status

Mega-CHOEP phase III is a randomised study comparing conventional chemoimmunotherapy with R-CHOEP-14 with high-dose chemotherapy plus Rituximab with autologous stem cell transplantation in high-risk patients aged 61 to 80 years with Aggressive Non-Hodgkin’s Lymphoma.

Baseline Data and Endpoints for MAXSEP

Baseline Data and Endpoints for HYPRESS

Baseline Data and Endpoints for SISPCT

Baseline Data and Endpoints for VISEP

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival) Sample Size: 103

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival)