Projects

Disease Title Motivation OMICS Datasets Clinical Datasets SOM Datasets Publications
DSHNHL 1999-1 (RICOVER-60 = rituximab plus CHOP in patients over 60)

The goal of the study was to evaluate the therapeutic efficacy of the Monoclonal anti-CD20 Antibody Rituximab and the increase of chemotherapy cycles from 6 to 8.

0 1 0 1
DSHNHL 2002-1 (MegaCHOEP Phase III)

The goal of the study was to evaluate the therapeutic efficacy of a high-dose therapy with autologous stem cell therapy.

0 1 0 1
Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)

In critical illness, a significant reduction in mortality was recently achieved by strict glycemic control, however it has to be determined whether this is true and safe for patients with sepsis as well.

0 0 0 2
Evaluation Metadata Repository

The aim of the MDR-Evaluation project was an evaluation of the possible application scenarios for metadata repositories by a larger group of experts. The focus was not on concrete software, but on the community's basic expectation of a web-based database of data elements.

0 0 0 2
Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome 0 0 1 1
Genetical Statistics and Systems Biology

The group is interested in omic-level studies including the genome, methylome, transcriptome, and metabolome of the general population as well as of various diseases including cardiovascular diseases, pneumonia, sepsis, obesity, and brain cancers. Additionally, we aim at transfering results of biomathematical model simulations into clinical practice e.g. by haematopoietic growth-factor…

2 0 0 2
Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome 0 0 2 2
German Consortium for Hereditary Breast and Ovarian Cancer

The aim of the GC-HBOC is to improve the cinical care of patients with a family history of breast and ovarian cancer in Germany through a network of specialised university centers providing structured interdisciplinary care. Furthermore, GC-HBOC collects comprehensive data on patients and families in a standardized manner, in order to promote research on hereditary breast and ovarian cancer.…

0 0 0 3
German Consortium for Hereditary Non-Polyposis Colorectal Cancer

The aim of the GC-HNPCC is to improve the cinical care of patients with Lynch syndrome in Germany through a network of specialised university centers providing structured interdisciplinary care. Furthermore, GC-HNPCC collects comprehensive data on patients and families in a standardized manner, in order to promote research on Lynch syndrome.

0 0 0 3
German Glioma Network

The combination of clinical data and moleculargenetic test results is of great value for science with the goal to achieve a better understanding of the molecular principles of brain tumors. This project opens new ways in diagnostics and therapy for neuro-oncology.

1 3 1 6
Haematotox calculator

The toxcalclulator was developed to support the decision-making process for special care and prophylaxis of patients with aggressive NHL receiving CHOP-like regimen.

0 0 0 1
Leipzig Melanoma Studies 1 0 2 4
Leipzig Research Center for Civilization Diseases. Head and Neck Group

The aim of the Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) is to facilitate improvements in the treatment and care of head and neck cancer patients through insights from molecular studies.

1 1 0 1
LIFE Adult Study

Ziel von LIFE ADULT ist es, mehr über Volkskrankheiten, wie z. B. Krebs, Diabetes oder Herz-Kreislauf-Erkrankungen herauszufinden. In Deutschland sind viele Menschen von diesen Krankheiten betroffen – und es werden täglich mehr. Alltag und Lebensqualität der Betroffenen, aber auch ihrer Angehörigen, sind oft stark beeinträchtigt. Mit den Forschungen hofft diese epidemiologische Studie…

0 8 4 352
LIFE Child Study 0 0 0 5
LIFE Heart Study

Ziel der LIFE-Herzstudie ist die Identifizierung von Biomarkern und molekulargenetischen Faktoren, die in Zusammenhang mit der Entstehung und weiteren Entwicklung von Atherosklerose und Herz­infarkt stehen. Auf dieser Grundlage wird zukünftig eine Entwicklung neuer präventiver und therapeutischer Ansätze erwartet.
Als Leipziger Herzstudie wurde das Projekt in Kooperation zwischen dem…

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LIFE- Leipzig Research Center for Civilization Diseases, Leipzig University

LIFE pursues the relevant challenges in medical research, namely to support individual health maintenance from childhood to aged people and to find risks for frequent diseases and new strategies for targeted prevention and therapies.

0 0 0 87
MabThera International Trial

The goal of the study was to evaluate the therapeutic efficacy of the Monoclonal anti-CD20 Antibody Rituximab.

0 2 0 2
MMML-MYC-SYS

With the knowledge achieved in this project new molecular classifiers will be identified to improve the diagnosis of this disease.

2 0 2 4
Natural Language Processing for Clinical Research

Ziel des NLP4CR Projektes ist es, zu prüfen, ob sich verfügbare NLP Techniken eignen, um medizinische Freitexte (Arztbriefe, Befunde) zu verarbeiten und die Rekrutierung von Patienten in klinische Studien zu unterstützen.

0 0 0 1
Onto-Med Research Group 0 0 0 1
oposSOM

This package translates microarray expression data into metadata of reduced dimension. It provides various sample-centered and group-centered visualizations, sample similarity analyses and functional enrichment analyses. The underlying SOM algorithm combines feature clustering, multidimensional scaling and dimension reduction, along with strong visualization capabilities. It enables extraction…

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