High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis of sepsis, but effect on outcome is unclear. We investigated whether high-dose intravenous sodium selenite treatment and
procalcitonin-guided anti-infectious therapy in patients with severe sepsis affect mortality.
Institut für Medizinische Informatik, Statistik und Epidemiologie (IMISE)