A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. [1]


Leipzig Melanoma Studies

The Leipzig Melanoma Studies project consists of studies of the Department of Dermatology, Venereology and Allergology (Leipzig University), Interdisciplinary Center for Bioinformatics (IZBI, Leipzig ...

LIFE Heart Study

Die LIFE-Heart Studie rekrutierte 7.000 Patienten mit Verdacht auf koronare Herzerkrankung, manifester Herzerkrankung oder Myokardinfarkt. Alle Patienten erhielten eine Koronarangiographie, so dass de...

Manchester Scoring System

The "Manchester Scoring System" is an empirical mutation risk prediction model. In its current form, a risk score for the identification of a pathogenic BRCA1/2 mutation is being calculated based on t...


The Claus model is a genetic breast cancer risk calculation model assuming a single rare, highly penetrant gene. The extended version of the Claus model (eClaus), as implemented in the commercial pedi...