Gene expression patterns and TP53 mutations are associated with HPV RNA status, lymph node metastasis, and survival in head and neck cancer (clinical Dataset)


Our first objective was to compare the molecular features of subgroups of HNSCC defined by their HPV16 DNA and RNA status. The second objective was to identify gene expression subtypes in HNSCC and to correlate them with other characteristics of the patients.

HPV DNA and RNA status, mutations of 50 genes, survival and other clinical characteristics of 270 patients with head and neck cancer
Study Design

Within the Leipzig Head and Neck Group (LHNG) we designed an observational cohort study to include consecutive patients with primary and metachronous secondary HNSCC of oral cavity, larynx, oro-, and hypopharynx. All tumors were pathohistologically classified as head and neck squamous cell carcinoma (ICDO-M-8070/3, 8071/3, 8083/3). Excluded from the study were patients with prior history of cancer other than HNSCC within the last 5 years.

Publication Date
Dr. Maciej Rosolowski
Contact Institution

Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
University of Leipzig
Härtelstr. 16-18
04107 Leipzig

Sample Size
Human Disease Ontology Concept