oposSOM: R-package for high-dimensional portraying of genome-wide expression landscapes on bioconductor.

Abstract
MOTIVATION: Comprehensive analysis of genome-wide molecular data challenges bioinformatics methodology in terms of intuitive visualization with single-sample resolution, biomarker selection, functional information mining and highly granular stratification of sample classes. oposSOM combines those functionalities making use of a comprehensive analysis and visualization strategy based on self-organizing maps (SOM) machine learning which we call 'high-dimensional data portraying'. The method was successfully applied in a series of studies using mostly transcriptome data but also data of other OMICs realms. AVAILABILITY AND IMPLEMENTATION: oposSOM is now publicly available as Bioconductor R package. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Study/Project
ID (DOI)
10.1093/bioinformatics/btv342
Publication Date
Corresponding Author
Dr. Henry Löffler-Wirth
Corresponding Author Institution

IZBI
Härtelstr. 16-18
04107 Leipzig

Corresponding Author email
wirth@izbi.uni-leipzig.de