Transcriptome Analytics Browser - Tour (part 1 of 5)
Background: Gene expression analysis of complex and high-dimensional data, for example in cancer studies or population studies , generates vast amounts of results, which are provided by the LHA in structured results data sets.
Problem: We performed analysis of more than 850 mature B-cell lymphomas along with healthy control samples using oposSOM pipeline to provide a holistic view on their expression landscape, the heterogeneity of activated gene-regulatory programs and their association with different subtypes of this disease.
Solution: For this we implemented analysis tools addressing four major tasks as presented in this tour.
The Leipzig Health Atlas is an alliance of medical ontologists, medical systems biologists and clinical trials groups to design and implement a multi-functional and quality-assured atlas. It provides models, data and metadata on specific use cases from medical research fields.