Claus models breast cancer in terms of a single, rare, highly penetrant gene.The extended version of the Claus model, as implemented in the commercial pedigree drawing software CYRILLIC 2.1.3, calculates BRCA1/2 mutation probabilities and breast cancer risks for female individuals (test persons) based on their personal and familial history of breast and ovarian cancer.
Methods & Phenotypes
GC-HBOC-MFE characterises the mutation prevalences in different family constellations with breast and ovarian cancers (BCOC) for different BCOC related genes (e.g. BRCA1, BRCA2, CHEK2, RAD51C,...) . Data stem from about 40.000 families that were gathered since 1996 in a clinical setting by the GC-HBOC, comprising full pedigrees with cancer status of all individual members at the time of first counselling, and the mutation status of the index patient.
The toxcalculator is a web-based tool to calculate prognostic scores on haematopoietic toxicity for 6 cycles CHOP-like regimen in patients with aggressive NHL.
We mapped measured hand grip data of the large LIFE Adult population (10,000 participants) onto the Leipzig map. In particular, we locate each participant at the time of participation in Leipzig and, thus, can derive hand grip strength averages (incl. mean, median) per specific city districts. The resulting data can be filtered by age bands and gender.
Preprocessing Illumina HT12v4 gene expression data including quality filtering, data transformation and normalisation and batch-effect removal as well as visualisation
The platform is intended for visualization of expression- and mutation-driven changes in biological pathway activities in cancer datasets available in ICGC. The impact of somatic mutations on protein-protein interactions were calculated using Mechismo. Overall activity of biological pathway was evaluated using Pathway Signal Flow algorithm. The application provides interactive heatmaps for pathway output sink node activities and pathway images with mapped affected interactions and output node activities.
LHAhpv16classifier - gene expression based predictor of the HPV16 status and of the molecular subgroup (as reported in Wichmann et al. 2015) of head and neck tumor samples
Classification of head and neck tumor samples into HPV-positive and negative samples based on their gene expression. Classification of the samples into molecular subgroups reported in Wichmann et al. 2015
This is a Shiny application to predict and to manage next-cycle thrombopenia due to CHOEP treatment based on the individual fits of the preceeding treatment cycles.
The Manchester scoring system is a tool to predict mutations risks for BRCA1/2 in families with multiple and/or early-onset cases of breast and ovarian cancers.
MMRpredict is a risk prediction model for patients with colorectal cancer only (Barnetson et al. 2006). It calculates the risk for having a mutation in MLH1, MSH2 and MSH6 (combined) based on the history of colorectal and endometrium cancers in the family (stage 1).