Interactive Pathway Activity Analysis platform

LHA-ID
7QWM5X316P-7
Description
The platform is intended for visualization of expression- and mutation-driven changes in biological pathway activities in cancer datasets available in ICGC. The impact of somatic mutations on protein-protein interactions were calculated using Mechismo. Overall activity of biological pathway was evaluated using Pathway Signal Flow algorithm. The application provides interactive heatmaps for pathway output sink node activities and pathway images with mapped affected interactions and output node activities.
Sponsor
Joint Projects PathwayMaps and oBIG of IMB, Yerevan and IZBI, Leipzig
Contact
Siras Hakobyan
Contact Institution

Institute of Molecular Biology
7 Ezras Hasratyan St, Yerevan, Armenien

Contact eMail
Version Number
1.0
Required Programs
none
Programing Language
R
Development Environment
R Studio