Network of discovered loci, eQTLs and metabolites

LHA-ID
7Q0CTG2NKG-1
Motivation

To visualize identified associations between SNPs, expressed genes, and metabolites as well as causal relations between gene-expression and metabolites

Description

Data for visualisation of associations and causal relationsships of SNPs, gene expression, and metabolites based on 1,856 individuals of the LIFE Heart study

Overall Design

We analyzed whole blood levels of amino acids and acylcarnitines, reflecting disease relevant metabolic pathways. For this, we performed a genome wide association analysis to discover genetic variants influencing metabolism. Thereby, we discovered six novel regions in the genome and confirmed ten regions previously found to be associated with metabolites in plasma, serum or urine. Subsequently, we analyzed whether these variants regulate gene-expression in peripheral mononuclear cells and at several loci we identified novel causal relations between SNPs, gene-expression and metabolite levels.

Publisher
PLoS Genetics
Contact
Prof. Dr. rer. nat. Markus Scholz
Contact Institution

Institut für Medizinische Informatik, Statistik und Epidemiologie (IMISE), Härtelstr. 16-18, 04107 Leipzig

Sample Size
1856
Data Level
Summary data for visualisation
Development Environment
RStudio
Programing Language
R
Sample Type