The "GC-HBOC Mutation Frequency Explorer" can be used to assist clinicians and genetic counselors in the clinical management of families suspected of having hereditary breast and ovarian cancer and to decide whether genetic testing should be performed.
The "GC-HBOC Mutation Frequency Explorer" is a tool to determine the observed frequencies of pathogenic BRCA1 and BRCA2 mutations based on familial cancer history data collected since 1996 by the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) in over 36,000 families suspected of having hereditary breast and ovarian cancer (Kast et al, 2016). This tool allows querying mutation frequencies for both predefined as well as flexibly customizable familial cancer histories.
Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
University of Leipzig