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Created: 25th Mar 2021 at 17:17
Last updated: 25th Mar 2021 at 17:17
Last used: 14th Apr 2021 at 15:14

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The aim of this project is to validate and improve an in vitro test system developed in a previous project for the prediction of hepatotoxicity induced by chemical substances and drugs. For this purpose, the test system will be supplemented with immunological cells in order to be able to detect idiosyncratic reactions. In the subproject of the working group of Prof. Daniel Seehofer and Dr. Georg Damm, primary liver cells will be provided and the in vitro model will be improved by Kupffer cells.
Programme: This Project is not associated with a Programme
Public web page: Not specified
Start date: 1st Feb 2017
End date: 31st Dec 2020
Organisms: Homo sapiens
Human Diseases: liver disease
Snapshots: No snapshots
Investigation: LivSys Transfer Investigation
Resources: Characterization of Liver macrophages in human liver tissue sections
Submitter: René Hänsel
Resource type: Image collection
Technology type: Imaging
Snapshots: No snapshots
Investigation: LivSys Transfer Investigation
Study: In vivo and in vitro characterization of primar...
Organisms: No organisms
Human Diseases: No human diseases
SOPs: No SOPs
Data files: CD68_Donor1_1, CD68_Donor1_2, CD68_Donor1_3, CD68_Donor1_4, CD68_Donor1_5
Projects: LHA - Leipzig Health Atlas, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, LIFE Heart, MMML - Molecular mechanisms in malignant lymphoma, GLA - German Lymphoma Alliance, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, MMML-MYC-SYS, NLP4CR - Natural Language Processing for Clinical Research, Genetical Statistics and Systems Biology, SepNet - German Competence Network Sepsis, LIFE Child, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, GGN - German Glioma Network, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, ProstataCA, SMITH - Smart Medical Information Technology for Healthcare, COVID-19 Leipzig, Management of health information systems, LivSys Transfer - Transfer of the LivSys in vitro system for hepatotoxicity into application, Project Test Demonstrator
Institutions: Institute for Medical Informatics, Statistics and Epidemiology

Roles: Technician
Expertise: Data Management, Data analysis, Python, Html
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_409
Synonyms: disorder of liver (disorder), hepatic disorder